Germline gain‐of‐function MMP11 variant results in an aggressive form of colorectal cancer
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Cancer"
DOI: 10.1002/ijc.34289
Abstract: Matrix metalloproteinase‐11 (MMP11) is an enzyme with proteolytic activity against matrix and nonmatrix proteins. Although most MMPs are secreted as inactive proenzymes and are later activated extracellularly, MMP11 is activated intracellularly by furin within the… read more here.
Keywords: germline gain; cancer germline; mmp11; colorectal cancer ... See more keywords
Metalloproteinase 11, potential marker and molecular target in advanced and castration-resistant prostate cancer. Culture study of peritumoral fibroblasts.
Sign Up to like & getrecommendations! Published in 2017 at "Actas urologicas espanolas"
DOI: 10.1016/j.acuro.2016.12.001
Abstract: OBJECTIVE To analyze the expression of metalloprotein 11 (MMP11) in cultured fibroblasts obtained from human prostate tumors with different clinical and pathological characteristics. MATERIAL AND METHODS For this study we analyzed samples of transrectal prostate… read more here.
Keywords: prostate; metalloproteinase potential; expression; castration ... See more keywords
MMP11 is associated with the immune response and immune microenvironment in EGFR-mutant lung adenocarcinoma
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2023.1055122
Abstract: Background High expression of matrix metalloproteinase-11 (MMP11) is associated with various tumors and immune microenvironments. Conversely, poor response to immunotherapy in epidermal growth factor receptor (EGFR)-mutant lung adenocarcinoma (LUAD) patients is closely related to the… read more here.
Keywords: egfr mutant; group; mmp11; expression ... See more keywords