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   Articles with "mmp13" as a keyword



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Design, cyclization, and optimization of MMP13-TIMP1 interaction-derived self-inhibitory peptides against chondrocyte senescence in osteoarthritis.

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recommendations! Published in 2019 at "International journal of biological macromolecules"

DOI: 10.1016/j.ijbiomac.2018.10.141

Abstract: The matrix metallopeptidase 13 (MMP13) is a central regulator of chondrocyte senescence that contributes to the development and progression of osteoarthritis (OA). In the present study, the native inhibitory structure of MMP13 in complex with… read more here.

Keywords: mmp13; site; inhibitory; mmp13 timp1 ... See more keywords
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Targeting articular Mmp13 in OA

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recommendations! Published in 2021 at "Nature Reviews Rheumatology"

DOI: 10.1038/s41584-021-00696-x

Abstract: Targeted nanoparticles that bind to exposed type II collagen in injured joints and promote localized downregulation of Mmp13 expression represent progress towards a disease-modifying osteoarthritis drug. read more here.

Keywords: targeting articular; rheumatology; articular mmp13; mmp13 ... See more keywords
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Sauchinone inhibits the proliferation, migration and invasion of breast cancer cells by suppressing Akt-CREB-MMP13 signaling pathway

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recommendations! Published in 2021 at "Bioscience Reports"

DOI: 10.1042/bsr20211067

Abstract: Abstract Sauchinone, a lignan isolated from Saururus chinenesis, is known to exhibit anti-inflammatory and anti-oxidant effects. Recently, sauchinone has been reported to inhibit the growth of various cancer cells, but its effects on breast cancer… read more here.

Keywords: cancer cells; cancer; breast cancer; creb ... See more keywords
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MicroRNA-4423-3p inhibits proliferation of fibroblast-like synoviocytes by targeting matrix metalloproteinase 13 in rheumatoid arthritis.

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recommendations! Published in 2021 at "Bioengineered"

DOI: 10.1080/21655979.2021.1988372

Abstract: Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that is increasing in incidence worldwide. RA is regulated by a variety of microRNAs (miRNAs/miR). Moreover, analysis of public data has revealed that miR-4423-3p is significantly… read more here.

Keywords: overexpression; mir; proliferation; mmp13 ... See more keywords
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Regulation of transforming growth factor-β1-stimulation of Runx2 acetylation for matrix metalloproteinase 13 expression in osteoblastic cells

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recommendations! Published in 2021 at "Biological Chemistry"

DOI: 10.1515/hsz-2021-0292

Abstract: Abstract Transforming growth factor beta 1 (TGF-β1) functions as a coupling factor between bone development and resorption. Matrix metalloproteinase 13 (MMP13) is important in bone remodeling, and skeletal dysplasia is caused by a deficiency in… read more here.

Keywords: factor; osteoblastic cells; runx2 acetylation; mmp13 ... See more keywords
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The Critical Role of MMP13 in Regulating Tooth Development and Reactionary Dentinogenesis Repair Through the Wnt Signaling Pathway

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recommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"

DOI: 10.3389/fcell.2022.883266

Abstract: Matrix-metalloproteinase-13 (MMP13) is important for bone formation and remodeling; however, its role in tooth development remains unknown. To investigate this, MMP13-knockout (Mmp13 −/− ) mice were used to analyze phenotypic changes in the dentin–pulp complex,… read more here.

Keywords: mmp13; signaling pathway; expression; tooth development ... See more keywords

Novel Pituitary Actions of Epidermal Growth Factor: Receptor Specificity and Signal Transduction for UTS1, EGR1, and MMP13 Regulation by EGF

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recommendations! Published in 2019 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms20205172

Abstract: Epidermal growth factor (EGF) is a member of the EGF-like ligands family, which plays a vital role in cell proliferation, differentiation, and folliculogenesis through binding with EGF receptors, including ErbB1 (EGFR/HER1), ErbB2 (HER2), ErbB3 (HER3),… read more here.

Keywords: egr1; uts1 egr1; mmp13; epidermal growth ... See more keywords