Chondrocyte‐Targeted Delivery System of Sortase A‐Engineered Extracellular Vesicles Silencing MMP13 for Osteoarthritis Therapy
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202303510
Abstract: Targeted drug delivery and the reduction of off‐target effects are crucial for the promising clinical application of nucleic acid drugs. To address this challenge, a new approach for treating osteoarthritis (OA) that accurately delivers antisense… read more here.
Keywords: extracellular vesicles; cap exoaso; mmp13; delivery ... See more keywords
Design, cyclization, and optimization of MMP13-TIMP1 interaction-derived self-inhibitory peptides against chondrocyte senescence in osteoarthritis.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2018.10.141
Abstract: The matrix metallopeptidase 13 (MMP13) is a central regulator of chondrocyte senescence that contributes to the development and progression of osteoarthritis (OA). In the present study, the native inhibitory structure of MMP13 in complex with… read more here.
Keywords: mmp13; site; inhibitory; mmp13 timp1 ... See more keywords
Targeting articular Mmp13 in OA
Sign Up to like & getrecommendations! Published in 2021 at "Nature Reviews Rheumatology"
DOI: 10.1038/s41584-021-00696-x
Abstract: Targeted nanoparticles that bind to exposed type II collagen in injured joints and promote localized downregulation of Mmp13 expression represent progress towards a disease-modifying osteoarthritis drug. read more here.
Keywords: targeting articular; rheumatology; articular mmp13; mmp13 ... See more keywords
Sauchinone inhibits the proliferation, migration and invasion of breast cancer cells by suppressing Akt-CREB-MMP13 signaling pathway
Sign Up to like & getrecommendations! Published in 2021 at "Bioscience Reports"
DOI: 10.1042/bsr20211067
Abstract: Abstract Sauchinone, a lignan isolated from Saururus chinenesis, is known to exhibit anti-inflammatory and anti-oxidant effects. Recently, sauchinone has been reported to inhibit the growth of various cancer cells, but its effects on breast cancer… read more here.
Keywords: cancer cells; cancer; breast cancer; creb ... See more keywords
MicroRNA-4423-3p inhibits proliferation of fibroblast-like synoviocytes by targeting matrix metalloproteinase 13 in rheumatoid arthritis.
Sign Up to like & getrecommendations! Published in 2021 at "Bioengineered"
DOI: 10.1080/21655979.2021.1988372
Abstract: Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that is increasing in incidence worldwide. RA is regulated by a variety of microRNAs (miRNAs/miR). Moreover, analysis of public data has revealed that miR-4423-3p is significantly… read more here.
Keywords: overexpression; mir; proliferation; mmp13 ... See more keywords
Regulation of transforming growth factor-β1-stimulation of Runx2 acetylation for matrix metalloproteinase 13 expression in osteoblastic cells
Sign Up to like & getrecommendations! Published in 2021 at "Biological Chemistry"
DOI: 10.1515/hsz-2021-0292
Abstract: Abstract Transforming growth factor beta 1 (TGF-β1) functions as a coupling factor between bone development and resorption. Matrix metalloproteinase 13 (MMP13) is important in bone remodeling, and skeletal dysplasia is caused by a deficiency in… read more here.
Keywords: factor; osteoblastic cells; runx2 acetylation; mmp13 ... See more keywords
Cancer-associated fibroblasts as facilitators in nasopharyngeal carcinoma progression via exosomal MMP13
Sign Up to like & getrecommendations! Published in 2025 at "Translational Cancer Research"
DOI: 10.21037/tcr-2025-428
Abstract: Background Cancer-associated fibroblasts (CAFs), essential components of the tumor microenvironment (TME), contribute to tumor formation. Our previous research demonstrated that exosomes containing matrix metalloproteinase 13 (MMP13) accelerate metastasis in nasopharyngeal carcinoma (NPC). This study aimed… read more here.
Keywords: mmp13; associated fibroblasts; nasopharyngeal carcinoma; cafs ... See more keywords
The Critical Role of MMP13 in Regulating Tooth Development and Reactionary Dentinogenesis Repair Through the Wnt Signaling Pathway
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.883266
Abstract: Matrix-metalloproteinase-13 (MMP13) is important for bone formation and remodeling; however, its role in tooth development remains unknown. To investigate this, MMP13-knockout (Mmp13 −/− ) mice were used to analyze phenotypic changes in the dentin–pulp complex,… read more here.
Keywords: mmp13; signaling pathway; expression; tooth development ... See more keywords
Combination of plasma MMPs and PD-1-binding soluble PD-L1 predicts recurrence in gastric cancer and the efficacy of immune checkpoint inhibitors in non-small cell lung cancer
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2024.1384731
Abstract: Background The tumor microenvironment (TME) impacts the therapeutic efficacy of immune checkpoint inhibitors (ICIs). No liquid biomarkers are available to evaluate TME heterogeneity. Here, we investigated the clinical significance of PD-1-binding soluble PD-L1 (bsPD-L1) in… read more here.
Keywords: cancer; bspd; mmp13; efficacy immune ... See more keywords
Novel Pituitary Actions of Epidermal Growth Factor: Receptor Specificity and Signal Transduction for UTS1, EGR1, and MMP13 Regulation by EGF
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms20205172
Abstract: Epidermal growth factor (EGF) is a member of the EGF-like ligands family, which plays a vital role in cell proliferation, differentiation, and folliculogenesis through binding with EGF receptors, including ErbB1 (EGFR/HER1), ErbB2 (HER2), ErbB3 (HER3),… read more here.
Keywords: egr1; uts1 egr1; mmp13; epidermal growth ... See more keywords