Design, cyclization, and optimization of MMP13-TIMP1 interaction-derived self-inhibitory peptides against chondrocyte senescence in osteoarthritis.
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DOI: 10.1016/j.ijbiomac.2018.10.141
Abstract: The matrix metallopeptidase 13 (MMP13) is a central regulator of chondrocyte senescence that contributes to the development and progression of osteoarthritis (OA). In the present study, the native inhibitory structure of MMP13 in complex with… read more here.
Keywords: mmp13; site; inhibitory; mmp13 timp1 ... See more keywords