Gallbladder cancer-associated genetic variants rs1003349 and rs1004030 regulate MMP14 expression by altering SOX10 and MYB binding sites.
Sign Up to like & getrecommendations! Published in 2023 at "Human molecular genetics"
DOI: 10.1093/hmg/ddad077
Abstract: The pathogenesis of gallbladder cancer is complex, involving environmental and genetic risk factors. The matrix metallopeptidase 14 (MMP14) alters the tumor microenvironment and promotes tumorigenesis. In this study, we have characterized the role of the… read more here.
Keywords: mmp14; expression; mmp14 expression; rs1004030 rs1003049 ... See more keywords
Abstract 6158: The relevance of endoglin and MMP14 to the metastatic potential of Ewing sarcoma cells
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/1538-7445.am2020-6158
Abstract: Background: Ewing sarcoma (ES) is a developmental bone/soft tissue neoplasia, for which mesenchymal stem cell (MSC) is the putative cell of origin. Although the outcome of ES patients bearing primary tumors has improved significantly, patients… read more here.
Keywords: eng; ewing sarcoma; mmp14; eng rm82 ... See more keywords
NOGO-B promotes EMT in lung fibrosis via MMP14 mediates free TGF-beta1 formation
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.20297
Abstract: Idiopathic pulmonary fibrosis (IPF) is a lung disease with an extremely poor prognosis. Epithelial mesenchymal transition (EMT) appearing on the airway epithelial cell plays an essential role in the formation and development of Idiopathic pulmonary… read more here.
Keywords: fibrosis; formation; tgf; free tgf ... See more keywords
Combinatorial engineering of N-TIMP2 variants that selectively inhibit MMP9 and MMP14 function in the cell
Sign Up to like & getrecommendations! Published in 2018 at "Oncotarget"
DOI: 10.18632/oncotarget.25885
Abstract: Developing selective inhibitors for proteolytic enzymes that share high sequence homology and structural similarity is important for achieving high target affinity and functional specificity. Here, we used a combination of yeast surface display and dual-color… read more here.
Keywords: specific inhibitors; mmp9 mmp14; target; mmp14 ... See more keywords
High expression of MMP14 is associated with progression and poor short-term prognosis in muscle-invasive bladder cancer.
Sign Up to like & getrecommendations! Published in 2020 at "European review for medical and pharmacological sciences"
DOI: 10.26355/eurrev_202006_21646
Abstract: OBJECTIVE To evaluate the short-term prognostic value of matrix metalloproteinase 14 (MMP14) in muscle-invasive bladder cancer (MIBC). PATIENTS AND METHODS Expression of MMP14 and clinical information from The Cancer Genome Atlas (TCGA) were mined in… read more here.
Keywords: bladder cancer; expression; mmp14; cancer ... See more keywords
Contribution of MMP14-expressing cancer-associated fibroblasts in the tumor immune microenvironment to progression of colorectal cancer
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.956270
Abstract: Matrix metalloproteinase 14 (MMP14) expression is implicated in progression of colorectal cancer, but its role in the tumor microenvironment (TME) has been unclear. The relevance of MMP14 to colorectal cancer progression was explored by analysis… read more here.
Keywords: progression colorectal; mmp14; colorectal cancer; tumor ... See more keywords
Extracellular Matrix Remodeling by Fibroblast-MMP14 Regulates Melanoma Growth
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DOI: 10.3390/ijms222212276
Abstract: Maintaining a balanced state in remodeling the extracellular matrix is crucial for tissue homeostasis, and this process is altered during skin cancer progression. In melanoma, several proteolytic enzymes are expressed in a time and compartmentalized… read more here.
Keywords: collagen; melanoma growth; extracellular matrix; matrix ... See more keywords
RNA interference-mediated silencing of ppGalNAc-T1 and ppGalNAc-T2 inhibits invasion and increases chemosensitivity potentially by reducing terminal α2,3 sialylation and MMP14 expression in triple‑negative breast cancer cells.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular medicine reports"
DOI: 10.3892/mmr.2017.6449
Abstract: Glycopeptide-preferring polypeptide N-acetylgalactosamine transferase (ppGalNAc‑T) is a key enzyme that initiates the formation of the first GalNAc monosaccharide to polypeptides at Thr/Ser residues by O‑linked glycosylation. In order to investigate the effects of ppGalNAc‑T1 and… read more here.
Keywords: invasion; breast cancer; glycosylation; mmp14 ... See more keywords