Post-transcriptional regulation of MMP2 mRNA by its interaction with miR-20a and Nucleolin in breast cancer cell lines.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular biology reports"
DOI: 10.1007/s11033-021-06261-9
Abstract: Matrix-metalloproteinase-2 (MMP2) is a foremost MMP, governing invasion of breast cancer cells during metastasis. miR-20a was reported to induce mesenchymal to epithelial transition in MDA-MB-231 cells and its endogenous expression varies directly with invasiveness of… read more here.
Keywords: mir 20a; mmp2; post transcriptional; breast cancer ... See more keywords
Mating induces production of MMP2 in the llama oviduct: Analysis of MMP2 effect on semen.
Sign Up to like & getrecommendations! Published in 2018 at "Animal reproduction science"
DOI: 10.1016/j.anireprosci.2018.03.016
Abstract: Ovulation of South American Camelids is induced by mating. After copulation, sperm are stored into the oviduct to be released near ovulation time. To study whether copulation induces matrix metalloproteinase-2 (MMP2) secretion in the oviduct,… read more here.
Keywords: mmp2; copulation; effect semen; mmp2 effect ... See more keywords
PAD1 promotes epithelial-mesenchymal transition and metastasis in triple-negative breast cancer cells by regulating MEK1-ERK1/2-MMP2 signaling.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer letters"
DOI: 10.1016/j.canlet.2017.08.019
Abstract: Peptidylargininedeiminase 1 (PAD1) catalyzes protein for citrullination, and this activity has been linked to the epidermal cornification. However, a role for PAD1 in tumorigenesis, including breast cancers has not been previously explored. Here we first… read more here.
Keywords: mmp2; breast; breast cancer; pad1 ... See more keywords
YY1 inhibits the migration and invasion of pancreatic ductal adenocarcinoma by downregulating the FER/STAT3/MMP2 signaling pathway.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer letters"
DOI: 10.1016/j.canlet.2019.07.019
Abstract: Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis and a high mortality rate. The transcription factor YY1 acts as an inhibitor of many types of tumors. We found that YY1 knockdown promoted the invasion and… read more here.
Keywords: mmp2; invasion; migration; cancer ... See more keywords
Long noncoding RNA HOTAIR functions as ceRNA to regulate MMP2 in paraquat induced lung epithelial-mesenchymal transition.
Sign Up to like & getrecommendations! Published in 2021 at "Toxicology"
DOI: 10.1016/j.tox.2021.152891
Abstract: Paraquat (PQ) poisoning induces epithelial-mesenchymal transition (EMT) in the lungs, resulting in pulmonary fibrosis with a poor prognosis. Although competitive endogenous RNA (ceRNA) networks are known to exert post-transcriptional regulatory effects, the roles of such… read more here.
Keywords: mmp2; hotair; rna; mir ... See more keywords
Trophoblast survival signaling during human placentation requires HSP70 activation of MMP2-mediated HBEGF shedding
Sign Up to like & getrecommendations! Published in 2017 at "Cell Death and Differentiation"
DOI: 10.1038/cdd.2017.104
Abstract: Survival of trophoblast cells in the low oxygen environment of human placentation requires metalloproteinase-mediated shedding of HBEGF and downstream signaling. A matrix metalloproteinase (MMP) antibody array and quantitative RT-PCR revealed upregulation of MMP2 post-transcriptionally in… read more here.
Keywords: mmp2; hbegf shedding; human placentation; trophoblast survival ... See more keywords
Glycosaminoglycans influence enzyme activity of MMP2 and MMP2/TIMP3 complex formation - Insights at cellular and molecular level
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-41355-2
Abstract: The extracellular matrix (ECM) is a highly dynamic network constantly remodeled by a fine-tuned protein formation and degradation balance. Matrix metalloproteinases (MMPs) constitute key orchestrators of ECM degradation. Their activity is controlled by tissue inhibitors… read more here.
Keywords: timp3 complex; mmp2; formation; timp3 ... See more keywords
Naringin dihydrochalcone potentially binds to catalytic domain of matrix metalloproteinase-2: molecular docking, MM-GBSA, and molecular dynamics simulation approach
Sign Up to like & getrecommendations! Published in 2022 at "Natural Product Research"
DOI: 10.1080/14786419.2022.2118746
Abstract: Abstract Matrix metalloproteinase-2 (MMP2), an extracellular matrix remodulating protein’s increased activity causes cancer-metastasis. Potential MMP2 inhibitors showed sever side-effects in clinical trials. Present study is focused on identification natural MMP2 inhibitor by applying molecular docking,… read more here.
Keywords: molecular docking; mmp2; catalytic domain; docking gbsa ... See more keywords
Bone marrow stromal cell antigen 2(BST2) suppresses the migration and invasion of trophoblasts in preeclampsia by downregulating matrix metallopeptidase 2(MMP2)
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2074712
Abstract: ABSTRACT Preeclampsia is a grievous pregnancy-related complication with an incidence of approximately 5∼7% in pregnant women. Placental abnormalities and decreased placental perfusion associated with impaired trophoblast invasion are early pathological findings of preeclampsia. BST2 is… read more here.
Keywords: migration invasion; bst2; mmp2; expression ... See more keywords
A10789 Effect of omega-3 fatty acids on the extracellular matrix and intercellular communication in the heart of hypertensive rats with altered thyroid status
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Hypertension"
DOI: 10.1097/01.hjh.0000548220.45764.7a
Abstract: Objectives: Hypertension is one of the factor which induce remodelation of extracellular matrix (ECM) and intercellular communication. Transforming growth factor &bgr; (TGF&bgr;), matrix metalloproteinases-2 (MMP2) and connexin 43 (Cx43) are proteins implicated in the origin… read more here.
Keywords: mmp2; thyroid status; cx43; altered thyroid ... See more keywords
Association of Maternal and Fetal Single-Nucleotide Polymorphisms in Metalloproteinase (MMP1, MMP2, MMP3, and MMP9) Genes with Preeclampsia
Sign Up to like & getrecommendations! Published in 2018 at "Disease Markers"
DOI: 10.1155/2018/1371425
Abstract: Background Metalloproteinases (MMPs) play a pivotal role during the process of trophoblast invasion and placentation. The appearance of five functional single-nucleotide polymorphisms (SNP) in the genes of the metalloproteinases most commonly implicated in the implantation… read more here.
Keywords: mmp2; mmp9; mmp1; preeclampsia ... See more keywords