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MMP7 cleaves remyelination‐impairing fibronectin aggregates and its expression is reduced in chronic multiple sclerosis lesions

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0 Published in 2018 at "Glia"

DOI: 10.1002/glia.23328

Abstract: Upon demyelination, transient expression of fibronectin precedes successful remyelination. However, in chronic demyelination observed in multiple sclerosis (MS), aggregates of fibronectin persist and contribute to remyelination failure. Accordingly, removing fibronectin (aggregates) would constitute an effective… read more here.

Keywords: remyelination; fibronectin; mmp7 cleaves; multiple sclerosis ... See more keywords