Structural Basis for the Inhibition of Mycobacterial MmpL3 by NITD-349 and SPIRO.
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DOI: 10.1016/j.jmb.2020.05.019
Abstract: Novel antitubercular agents are urgently needed to combat the emergence of global drug resistance to human tuberculosis (TB). Mycobacterial membrane protein Large 3 (MmpL3) is a promising drug target because its activity is essential and… read more here.
Keywords: structural basis; basis inhibition; 349 spiro; drug ... See more keywords
Common Biological Properties of Mycobacterium tuberculosis MmpL3 Inhibitors
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DOI: 10.1021/acsinfecdis.5c00394
Abstract: MmpL3 is a promising new target for antitubercular drugs, but the microbiological properties of MmpL3 inhibitors are not fully understood. We compared the activity and mode of action of 11 structurally diverse compound series that… read more here.
Keywords: biological properties; tuberculosis; mmpl3; mmpl3 inhibitors ... See more keywords