Switches of tyrosine‐kinase inhibitors in chronic phase of chronic myeloid leukemia in real life
Sign Up to like & getrecommendations! Published in 2018 at "American Journal of Hematology"
DOI: 10.1002/ajh.25217
Abstract: To the Editor: Imatinib has transformed chronic myeloid leukemia (CML) prognosis with a survival rate of almost 83% at 10 years. The second and third generations of tyrosine-kinase inhibitors (TKIs) have enlarged the therapeutic possibilities.… read more here.
Keywords: first line; group; switch group; leukemia ... See more keywords
APC mutations are common in adenomas but infrequent in adenocarcinomas of the non-ampullary duodenum
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Gastroenterology"
DOI: 10.1007/s00535-021-01823-x
Abstract: Recent studies highlighted the clinicopathological heterogeneity of non-ampullary duodenal adenomas and adenocarcinomas, but the detailed process of the malignant transformation remains unclear. We analyzed 144 adenomas and 54 adenocarcinomas of the non-ampullary duodenum for immunohistochemical… read more here.
Keywords: adenoma; adenomas adenocarcinomas; non ampullary; mmr ... See more keywords
Clinical Translation of [68Ga]Ga-NOTA-anti-MMR-sdAb for PET/CT Imaging of Protumorigenic Macrophages
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Imaging and Biology"
DOI: 10.1007/s11307-018-01302-5
Abstract: PurposeMacrophage mannose receptor (MMR, CD206) expressing tumor-associated macrophages (TAM) are protumorigenic and was reported to negatively impact therapy responsiveness and is associated with higher chances of tumor relapse following multiple treatment regimens in preclinical tumor models.… read more here.
Keywords: nota anti; anti mmr; mmr sdab; mmr ... See more keywords
Mumps Antibody Titer in MMR-Vaccinated and Vaccine Naïve Children at a Public Hospital in Delhi
Sign Up to like & getrecommendations! Published in 2021 at "Indian Pediatrics"
DOI: 10.1007/s13312-021-2129-2
Abstract: To compare the mumps antibody titers in Measles-Mumps-Rubella (MMR)-vaccinated and vaccine naive children. This cross-sectional study was conducted at a tertiary-care public hospital in Delhi from November, 2016 to April, 2018 among 78 healthy children… read more here.
Keywords: vaccinated vaccine; mmr vaccinated; public hospital; mmr ... See more keywords
Up-regulation of MSH6 is associated with temozolomide resistance in human glioblastoma.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.01.093
Abstract: The impact of DNA mismatch repair (MMR) on resistance to temozolomide (TMZ) therapy in patients with glioblastoma (GBM) is recently reported but the mechanisms are not understood. We aim to analyze the correlation between MMR… read more here.
Keywords: msh6; regulation msh6; tmz; resistance ... See more keywords
Variants of DNA mismatch repair genes derived from 33,998 Chinese individuals with and without cancer reveal their highly ethnic-specific nature.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of cancer"
DOI: 10.1016/j.ejca.2019.11.004
Abstract: PURPOSE DNA mismatch repair (MMR) genes play important roles in maintaining genome stability. Mutations in MMR genes disrupt their mismatch repair function, cause genome instability and lead to increased risk of cancer in the mutation carriers… read more here.
Keywords: mmr variation; mmr; cancer; mismatch repair ... See more keywords
A novel measles outbreak control strategy in the Netherlands in 2013-2014 using a national electronic immunization register: A study of early MMR uptake and its determinants.
Sign Up to like & getrecommendations! Published in 2017 at "Vaccine"
DOI: 10.1016/j.vaccine.2017.09.018
Abstract: BACKGROUND During a large measles outbreak in the Netherlands in 2013-2014, infants aged 6-14months living in municipalities with low ( read more here.
Keywords: 2013 2014; early mmr; measles outbreak; mmr uptake ... See more keywords
Immunogenicity and safety of measles-mumps-rubella vaccine at two different potency levels administered to healthy children aged 12-15 months: A phase III, randomized, non-inferiority trial.
Sign Up to like & getrecommendations! Published in 2018 at "Vaccine"
DOI: 10.1016/j.vaccine.2018.07.076
Abstract: BACKGROUND The potency of live viral vaccines decreases over time. We compared the immunogenicity and safety of GSK measles-mumps-rubella vaccine (MMR-RIT) formulations at two different potencies with that of the commercially-available MMR II formulation. METHODS… read more here.
Keywords: potency; non inferiority; safety; mmr ... See more keywords
Parental attitudes and decisions regarding MMR vaccination during an outbreak of measles among an undervaccinated Somali community in Minnesota.
Sign Up to like & getrecommendations! Published in 2020 at "Vaccine"
DOI: 10.1016/j.vaccine.2020.09.022
Abstract: Incidence of measles is increasing in the US, largely due to transmission among growing unvaccinated communities. To elucidate predictors of parental decision to obtain measles, mumps, and rubella (MMR) vaccine for unvaccinated children during a… read more here.
Keywords: community minnesota; among undervaccinated; mmr vaccination; somali community ... See more keywords
Epigenetic silencing of MLH1 in endometrial cancers is associated with larger tumor volume, increased rate of lymph node positivity and reduced recurrence-free survival.
Sign Up to like & getrecommendations! Published in 2017 at "Gynecologic oncology"
DOI: 10.1016/j.ygyno.2017.07.003
Abstract: OBJECTIVES To determine the relationship between mismatch repair (MMR) classification and clinicopathologic features including tumor volume, and explore outcomes by MMR class in a contemporary cohort. METHODS Single institution cohort evaluating MMR classification for endometrial… read more here.
Keywords: mlh1; volume; tumor volume; epigenetic mmr ... See more keywords
Real-world prevalence of microsatellite instability testing and related status in women with advanced endometrial cancer in the United States
Sign Up to like & getrecommendations! Published in 2021 at "Gynecologic Oncology"
DOI: 10.1016/s0090-8258(21)01140-9
Abstract: Objectives: Microsatellite instability (MSI) due to a defective DNA mismatch repair (MMR) system has demonstrated increasing significance as a prognostic biomarker in solid tumors. With recent advancement in newer targeted therapies, understanding the MSI and… read more here.
Keywords: real world; msi; msi mmr; status women ... See more keywords