Mismatch Repair Deficiency Testing in Patients With Colorectal Cancer and Nonadherence to Testing Guidelines in Young Adults
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DOI: 10.1001/jamaoncol.2017.3580
Abstract: Importance Mismatch repair (MMR) deficiency of DNA has been observed in up to 15% of sporadic colorectal cancers (CRCs) and is a characteristic feature of Lynch syndrome, which has a higher incidence in young adults… read more here.
Keywords: testing guidelines; deficiency testing; mmr deficiency; mismatch repair ... See more keywords
Three molecular pathways model colorectal carcinogenesis in Lynch syndrome
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DOI: 10.1002/ijc.31300
Abstract: Lynch syndrome is caused by germline mutations of DNA mismatch repair (MMR) genes. MMR deficiency has long been regarded as a secondary event in the pathogenesis of Lynch syndrome colorectal cancers. Recently, this concept has… read more here.
Keywords: colorectal carcinogenesis; carcinogenesis lynch; colorectal cancers; mmr deficiency ... See more keywords