The prognostic and immunomodulatory role of the MMR system in patients with stomach adenocarcinoma
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-024-84613-8
Abstract: The mismatch repair (MMR) system plays a crucial role in the maintenance of DNA replication fidelity and genomic stability. The clinical value of the MMR molecular marker as an immunotherapy for advanced solid tumors has… read more here.
Keywords: mmr; stomach adenocarcinoma; expression; mmr system ... See more keywords
Analysis of age, tumor-sidedness, and mismatch repair (MMR) genes with response to immune checkpoint inhibitors (ICIs) in MMR-deficient (dMMR) colorectal cancer (CRC) patients (pts): A multi-institutional study.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2019.37.15_suppl.e15029
Abstract: e15029 Background: ICIs induce durable responses in dMMR CRC pts with overall response rates (ORR) of 30-50%. Even though the loss of expression of any MMR gene predicts ICIs response, it is unknown if ORRs… read more here.
Keywords: response; sided tumors; mmr genes; crc ... See more keywords
Mutations in Mismatch Repair Genes and Microsatellite Instability Status in Pancreatic Cancer
Sign Up to like & getrecommendations! Published in 2024 at "Cancers"
DOI: 10.3390/cancers16112111
Abstract: Simple Summary Immunotherapy may be beneficial for pancreatic cancer (PC) patients with mismatch repair (MMR) deficiency. Although it is known that MMR deficiency (MMR-D) can result from mutations in MMR genes, the prevalence of these… read more here.
Keywords: mismatch repair; mmr; msi; status ... See more keywords
Pathogenic Insights into DNA Mismatch Repair (MMR) Genes–Proteins and Microsatellite Instability: Focus on Adrenocortical Carcinoma and Beyond
Sign Up to like & getrecommendations! Published in 2023 at "Diagnostics"
DOI: 10.3390/diagnostics13111867
Abstract: DNA damage repair pathways, including mismatch repair (MMR) genes, are prone to carcinoma development in certain patients. The assessment of the MMR system is widely recognized as part of strategies concerning solid tumors (defective MMR… read more here.
Keywords: mismatch repair; mmr; case; mmr genes ... See more keywords
A Previously Unrecognized Molecular Landscape of Lynch Syndrome in the Mexican Population
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms231911549
Abstract: Lynch syndrome (LS) is the main hereditary colorectal cancer syndrome. There have been few reports regarding the clinical and molecular characteristics of LS patients in Latin America; this is particularly true in the Mexican population,… read more here.
Keywords: previously unrecognized; unrecognized molecular; lynch syndrome; mexican population ... See more keywords
Defects in MMR Genes as a Seminal Example of Personalized Medicine: From Diagnosis to Therapy
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Personalized Medicine"
DOI: 10.3390/jpm11121333
Abstract: Microsatellite instability (MSI) is the landmark feature of DNA mismatch repair deficiency, which can be found in 15–20% of all colorectal cancers (CRC). This specific set of tumors has been initially perceived as a niche… read more here.
Keywords: msi; medicine; diagnosis; mmr genes ... See more keywords