Frequent Mismatch Repair Protein Deficiency in Mixed Endometrioid and Clear Cell Carcinoma of the Endometrium
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DOI: 10.1097/pgp.0000000000000369
Abstract: Mixed endometrioid and clear cell carcinoma of the endometrium refers to a scenario in which the tumor exhibits histologic features of both endometrioid and clear cell carcinoma. We observed a tendency for these tumors to… read more here.
Keywords: cell; cell carcinoma; mmr protein; endometrioid clear ... See more keywords
Morphological predictors for microsatellite instability in urothelial carcinoma
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DOI: 10.1186/s13000-021-01168-2
Abstract: Introduction Microsatellite instability occurs due to a series of mutations in the DNA pairing error repair (Mismatch repair; MMR) genes, which can affect germ cells as occurs in Lynch syndrome, whose patients are at high… read more here.
Keywords: instability; urothelial carcinomas; loss mmr; mmr protein ... See more keywords
Clinicopathological characteristics and loss of mismatch repair protein expression in Chinese upper tract urothelial carcinomas
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DOI: 10.3389/fonc.2022.1012168
Abstract: Expression of DNA mismatch repair (MMR) protein (MLH1, PMS2, MSH2, and MSH6) in upper tract urothelial carcinoma (UTUC) has been explored in Western cohorts, but it is rarely reported in Eastern cohorts. We aimed to… read more here.
Keywords: loss mmr; protein expression; loss; expression ... See more keywords
Identification of Germline Mutations in Upper Tract Urothelial Carcinoma With Suspected Lynch Syndrome
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DOI: 10.3389/fonc.2022.774202
Abstract: Objective Whole-exon sequencing (WES) is a commercially available tool for hereditary disease testing. However, little is known about hereditary upper-tract urothelial carcinoma (UTUC) in the Chinese population. This study aims to investigate the prevalence of… read more here.
Keywords: germline mutations; protein staining; tract urothelial; upper tract ... See more keywords
[Expression and clinical significance of MMR protein and MLH1 promoter methylation testing in endometrial cancer].
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DOI: 10.3760/cma.j.issn.0529-567x.2018.12.005
Abstract: Objective: To explore the expression and clinical significance of mismatch repair (MMR) protein and MLH1 promoter methylation testing in endometrial cancer (EC) . Methods: A total of 420 cases with EC diagnosed by the surgical… read more here.
Keywords: methylation; expression; mmr protein; expression loss ... See more keywords