MMTV does not encode viral microRNAs but alters the levels of cancer-associated host microRNAs.
Sign Up to like & getrecommendations! Published in 2018 at "Virology"
DOI: 10.1016/j.virol.2017.09.030
Abstract: Mouse mammary tumor virus (MMTV) induces breast cancer in mice in the absence of known virally-encoded oncogenes. Tumorigenesis by MMTV is thought to occur primarily through insertional mutagenesis, leading to the activation of cellular proto-oncogenes… read more here.
Keywords: mmtv encode; encode viral; host mirnas; host ... See more keywords
Transactivation of the novel 5’ cis-acting element of mouse mammary tumor virus (MMTV) by human retroviral transactivators Tat and Tax
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DOI: 10.1038/s42003-024-07139-9
Abstract: The mouse mammary tumor virus (MMTV) encodes a 5’ element crucial for transcription of its genome along with the Rem/Rem-responsive element (RmRE) responsible for nuclear export of this unspliced RNA. Whether the 5’ element is… read more here.
Keywords: mammary tumor; mmtv; mouse mammary; tax ... See more keywords
A Retrotranslocation Assay That Predicts Defective VCP/p97-Mediated Trafficking of a Retroviral Signal Peptide
Sign Up to like & getrecommendations! Published in 2022 at "mBio"
DOI: 10.1128/mbio.02953-21
Abstract: Endoplasmic reticulum-associated degradation (ERAD) is a form of cellular protein quality control that is manipulated by viruses, including the betaretrovirus, mouse mammary tumor virus (MMTV). MMTV-encoded signal peptide (SP) has been shown to interact with… read more here.
Keywords: mmtv; signal peptide; retrotranslocation; vcp ... See more keywords
Involvement of APOBEC3A/B Deletion in Mouse Mammary Tumor Virus (MMTV)-like Positive Human Breast Cancer
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DOI: 10.3390/diagnostics13061196
Abstract: The association between mouse mammary tumor virus (MMTV)-like sequences and human breast cancer (BC) is largely documented in the literature, but further research is needed to determine how they influence carcinogenesis. APOBEC3 cytidine deaminases are… read more here.
Keywords: mmtv like; apobec3a deletion; tumor; cancer ... See more keywords
Mouse Mammary Tumour Virus (MMTV) in Human Breast Cancer—The Value of Bradford Hill Criteria
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DOI: 10.3390/v14040721
Abstract: For many decades, the betaretrovirus, mouse mammary tumour virus (MMTV), has been a causal suspect for human breast cancer. In recent years, substantial new evidence has been developed. Based on this evidence, we hypothesise that… read more here.
Keywords: breast; breast cancer; human breast; virus ... See more keywords
Mouse Mammary Tumor Virus (MMTV) and MMTV-like Viruses: An In-depth Look at a Controversial Issue
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DOI: 10.3390/v14050977
Abstract: Since its discovery as a milk factor, mouse mammary tumor virus (MMTV) has been shown to cause mammary carcinoma and lymphoma in mice. MMTV infection depends upon a viral superantigen (sag)-induced immune response and exploits… read more here.
Keywords: mammary tumor; mouse mammary; mmtv like; tumor virus ... See more keywords
The Viral Origin of Human Breast Cancer: From the Mouse Mammary Tumor Virus (MMTV) to the Human Betaretrovirus (HBRV)
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DOI: 10.3390/v14081704
Abstract: A Human Betaretrovirus (HBRV) has been identified in humans, dating as far back as about 4500 years ago, with a high probability of it being acquired by our species around 10,000 years ago, following a… read more here.
Keywords: mammary tumor; tumor virus; breast cancer; mmtv ... See more keywords