Small Extracellular Vesicles Orchestrate Cisplatin‐Induced Ototoxicity: Potential Biomarker and Targets Discovery
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Science"
DOI: 10.1002/advs.202502627
Abstract: Cisplatin‐induced ototoxicity remains a clinical dilemma with limited mechanistic understanding and no food and drug administration (FDA)‐approved therapies. Despite emerging roles of small extracellular vesicles (sEV) in drug ototoxicity, their molecular cargo profiles and causal… read more here.
Keywords: cisplatin; induced ototoxicity; mmu mir; cis sev ... See more keywords
Exploring tumourigenic potential of the parasite Anisakis: a pilot study
Sign Up to like & getrecommendations! Published in 2018 at "Parasitology Research"
DOI: 10.1007/s00436-018-6008-2
Abstract: Anisakiasis is a global disease caused by consumption of raw or lightly cooked fish parasitised with Anisakis spp. third-stage larvae. Cases in the literature show colocalised anisakiasis and colorectal cancer, and the incidental finding of… read more here.
Keywords: mmu mir; cancer related; anisakis; cancer ... See more keywords
MicroRNA mmu-miR-511-5p: A promising Diagnostic Biomarker in Experimental Toxoplasmosis Using Different Strains and Infective Doses in Mice with Different Immune States Before and After Treatment
Sign Up to like & getrecommendations! Published in 2024 at "Acta Parasitologica"
DOI: 10.1007/s11686-024-00851-w
Abstract: Searching for a novel early diagnostic biomarker for toxoplasmosis, real-time-PCR was currently used to measure the serum mmu-miR-511-5p level in male Swiss-albino mice infected with either; ME49 or RH Toxoplasma gondii (T. gondii) strains. Three… read more here.
Keywords: mir 511; mmu mir; treatment; diagnostic biomarker ... See more keywords
Mmu‐miR‐92a‐2‐5p targets TLR2 to relieve Schistosoma japonicum‐induced liver fibrosis
Sign Up to like & getrecommendations! Published in 2019 at "International Immunopharmacology"
DOI: 10.1016/j.intimp.2019.01.007
Abstract: &NA; According to conservative estimates, >230 million people are infected with schistosomiasis,which becomes one of the most common parasitic diseases. This study focuses on investigating in vivo and in vitro effects of mmu‐miR‐92a‐2‐5p in Schistosoma… read more here.
Keywords: induced liver; liver fibrosis; mmu mir; japonicum induced ... See more keywords
Paternal nicotine exposure defines different behavior in subsequent generation via hyper-methylation of mmu-miR-15b
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-07920-3
Abstract: The neurobehavioral effects of paternal smoking and nicotine use have not been widely reported. In the present study, nicotine exposure induced depression in the paternal generation, but reduced depression and promoted hyperactivity in F1 offspring.… read more here.
Keywords: generation; mir 15b; nicotine exposure; mmu mir ... See more keywords
Bioinformatics analysis of miRNAs germacrone protection on diabetic nephropathy
Sign Up to like & getrecommendations! Published in 2024 at "Scientific Reports"
DOI: 10.1038/s41598-024-81944-4
Abstract: Diabetes nephropathy (DN) is a prevalent and severe microvascular diabetic complication. Despite the recent developments in germacrone-based therapies for DN, the underlying mechanisms of germacrone in DN remain poorly understood. This study used comprehensive bioinformatics… read more here.
Keywords: group; mmu mir; bioinformatics analysis; germacrone ... See more keywords
Differential Expression of miRNAs by Anti-Obesity Treatment Sulforaphane in Skeletal Muscle of Diet-Induced Obesity in Mice
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5732853
Abstract: Background: Skeletal muscles comprise 40–60% of the body's total weight and 30% of the metabolic rate at rest. As the primary site for glucose uptake into tissues by insulin induction, it is crucial for metabolic… read more here.
Keywords: obesity; mmu mir; physiology; skeletal muscle ... See more keywords
Effects of Icariin on Atherosclerosis and Predicted Function Regulatory Network in ApoE Deficient Mice
Sign Up to like & getrecommendations! Published in 2018 at "BioMed Research International"
DOI: 10.1155/2018/9424186
Abstract: Objective. Icariin plays a pivotal role in ameliorating atherosclerosis for animal models although its comprehensive biological role remains largely unexplored. This study aimed to fully understand the effects of icariin on atherosclerosis in high-fat diet-induced… read more here.
Keywords: network; mmu mir; icariin atherosclerosis; effects icariin ... See more keywords
Transcriptional landscape of intestinal environment in DSS-induced ulcerative colitis mouse model
Sign Up to like & getrecommendations! Published in 2024 at "BMC Gastroenterology"
DOI: 10.1186/s12876-024-03128-8
Abstract: Ulcerative colitis (UC) is a chronic inflammatory disease that targets the colon and has seen an increasing prevalence worldwide. In our pursuit of new diagnostic and therapeutic approaches for UC, we undertook a sequencing of… read more here.
Keywords: mir mmu; mmu mir; mmu; ulcerative colitis ... See more keywords
Regulation of hepatic microRNAs in response to early stage Echinococcus multilocularis egg infection in C57BL/6 mice
Sign Up to like & getrecommendations! Published in 2020 at "PLoS Neglected Tropical Diseases"
DOI: 10.1371/journal.pntd.0007640
Abstract: We present a comprehensive analysis of the hepatic miRNA transcriptome at one month post-infection of experimental primary alveolar echinococcosis (AE), a parasitic infection caused upon ingestion of E. multilocularis eggs. Liver tissues were collected from… read more here.
Keywords: c57bl mice; infection; mmu mir; expression ... See more keywords
Bioinformatics analysis of microarray data to explore the key genes involved in HSF4 mutation-induced cataract.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of ophthalmology"
DOI: 10.18240/ijo.2018.06.03
Abstract: AIM To reveal the mechanisms of heat-shock transcription factor 4 (HSF4) mutation-induced cataract. METHODS GSE22362, including 3 HSF4-null lens and 3 wild-type lens, was obtained from Gene Expression Omnibus database. After data preprocessing, the differentially… read more here.
Keywords: network; mutation induced; mmu mir; hsf4 mutation ... See more keywords