Stress keratin 17 and estrogen support viral persistence and modulate the immune environment during cervicovaginal murine papillomavirus infection.
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2214225120
Abstract: A murine papillomavirus, MmuPV1, infects both cutaneous and mucosal epithelia of laboratory mice and can be used to model high-risk human papillomavirus (HPV) infection and HPV-associated disease. We have shown that estrogen exacerbates papillomavirus-induced cervical… read more here.
Keywords: estrogen; papillomavirus; disease; infection ... See more keywords
A Novel In Vivo Infection Model To Study Papillomavirus-Mediated Disease of the Female Reproductive Tract
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DOI: 10.1128/mbio.00180-19
Abstract: Tractable and efficient models of papillomavirus-induced pathogenesis are limited due to the strict species-specific and tissue-specific tropism of these viruses. Here, we report a novel preclinical murine model of papillomavirus-induced cervicovaginal disease in wild-type, immunocompetent… read more here.
Keywords: infection; papillomavirus induced; mmupv1; model ... See more keywords
Cutaneous HPV8 and MmuPV1 E6 Proteins Target the NOTCH and TGF-β Tumor Suppressors to Inhibit Differentiation and Sustain Keratinocyte Proliferation
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DOI: 10.1371/journal.ppat.1006171
Abstract: Cutaneous beta-papillomaviruses are associated with non-melanoma skin cancers that arise in patients who suffer from a rare genetic disorder, Epidermodysplasia verruciformis (EV) or after immunosuppression following organ transplantation. Recent studies have shown that the E6… read more here.
Keywords: mmupv1; hpv8 mmupv1; mmupv1 proteins; notch tgf ... See more keywords
MmuPV1 E7’s interaction with PTPN14 delays Epithelial differentiation and contributes to virus-induced skin disease
Sign Up to like & getrecommendations! Published in 2023 at "PLOS Pathogens"
DOI: 10.1371/journal.ppat.1011215
Abstract: Human papillomaviruses (HPVs) contribute to approximately 5% of all human cancers. Species-specific barriers limit the ability to study HPV pathogenesis in animal models. Murine papillomavirus (MmuPV1) provides a powerful tool to study the roles of… read more here.
Keywords: induced lesions; ptpn14; epithelial differentiation; mmupv1 ... See more keywords
A Novel In Vivo Model of Laryngeal Papillomavirus-Associated Disease Using Mus musculus Papillomavirus
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DOI: 10.3390/v14051000
Abstract: Recurrent respiratory papillomatosis (RRP), caused by laryngeal infection with low-risk human papillomaviruses, has devastating effects on vocal communication and quality of life. Factors in RRP onset, other than viral presence in the airway, are poorly… read more here.
Keywords: papillomavirus; disease; infection; mmupv1 ... See more keywords
Expanded Basal Compartment and Disrupted Barrier in Vocal Fold Epithelium Infected with Mouse Papillomavirus MmuPV1
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DOI: 10.3390/v14051059
Abstract: Laryngeal infection with low-risk human papillomaviruses can cause recurrent respiratory papillomatosis (RRP), a disease with severe effects on vocal fold epithelium resulting in impaired voice function and communication. RRP research has been stymied by limited… read more here.
Keywords: expanded basal; fold epithelium; disease; vocal fold ... See more keywords
A novel lineage-tracing mouse model for studying early MmuPV1 infections
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.7554/elife.72638
Abstract: Human papillomaviruses are DNA viruses that ubiquitously infect humans and have been associated with hyperproliferative lesions. The recently discovered mouse specific papillomavirus (MmuPV1) provides the opportunity to study papillomavirus infections in vivo in the context… read more here.
Keywords: model; lineage tracing; mouse model; mmupv1 ... See more keywords