Allosteric coupling between Mn2+ and dsDNA controls the catalytic efficiency and fidelity of cGAS
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DOI: 10.1093/nar/gkaa084
Abstract: Abstract Cyclic-G/AMP (cGAMP) synthase (cGAS) triggers host innate immune responses against cytosolic double-stranded (ds)DNA arising from genotoxic stress and pathogen invasion. The canonical activation mechanism of cGAS entails dsDNA-binding and dimerization. Here, we report an… read more here.
Keywords: cgas; mn2 dsdna; coupling mn2; activation ... See more keywords