Anthraquinone-based Ligand as MNase Inhibitor: Insights from Inhibition Studies and Generation of a Payload Nanocarrier for Potential Anti-MRSA Therapy.
Sign Up to like & getrecommendations! Published in 2023 at "ChemMedChem"
DOI: 10.1002/cmdc.202200711
Abstract: The present study highlights the prospect of an anthraquinone-based ligand (C1) as an inhibitor of micrococcal nuclease (MNase) enzyme secreted by Staphylococcus aureus. MNase inhibition rendered by 5.0 µM C1 was ~96% and the ligand… read more here.
Keywords: inhibition; mnase; based ligand; anthraquinone based ... See more keywords
Application of MNase-Seq in the Global Mapping of Nucleosome Positioning in Plants.
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DOI: 10.1007/978-1-4939-8657-6_21
Abstract: The precise positioning of nucleosomes along the underlying DNA is critical for a variety of biological processes, especially in regulating transcription. The interplay between nucleosomes and transcription factors for accessing the underlying DNA sequences is… read more here.
Keywords: mnase seq; mapping nucleosome; nucleosome positioning; mnase ... See more keywords
High Sensitivity Profiling of Chromatin Structure by MNase-SSP
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DOI: 10.1016/j.celrep.2019.02.007
Abstract: SUMMARY A complete view of eukaryotic gene regulation requires that we accurately delineate how transcription factors (TFs) and nucleosomes are arranged along linear DNA in a sensitive, unbiased manner. Here we introduce MNase-SSP, a single-stranded… read more here.
Keywords: sensitivity profiling; mnase ssp; profiling chromatin; high sensitivity ... See more keywords