Progress in developing MNK inhibitors.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2021.113420
Abstract: The MNKs (mitogen-activated protein kinase-interacting protein kinases) phosphorylate eIF4E (eukaryotic initiation factor 4 E) at serine 209; eIF4E plays an important role in the translation of cytoplasmic mRNAs, all of which possess a 5' 'cap' structure… read more here.
Keywords: mnk; developing mnk; chemistry; progress developing ... See more keywords
Investigating the interaction between the intestinal epithelium and group-3 innate lymphoid cells in response to Clostridioides difficile toxins
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5731323
Abstract: Hypothesis: Upon disruption of the colonic epithelium, Clostridioides difficile toxins A and B (TcdAB) are thought to signal through to underlying immune cells. Amongst these are group-3 innate lymphoid cells (ILC3s), which modulate pathogen defense… read more here.
Keywords: mnk; epithelium; physiology; mnk cells ... See more keywords
XIAP Regulation by MNK Links MAPK and NFκB Signaling to Determine an Aggressive Breast Cancer Phenotype.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer research"
DOI: 10.1158/0008-5472.can-17-1667
Abstract: Hyperactivation of the NFκB pathway is a distinct feature of inflammatory breast cancer (IBC), a highly proliferative and lethal disease. Gene expression studies in IBC patient tissue have linked EGFR (EGFR/HER2)-mediated MAPK signaling to NFκB… read more here.
Keywords: mnk; breast cancer; mapk signaling; xiap ... See more keywords
TSC patient-derived isogenic neural progenitor cells reveal altered early neurodevelopmental phenotypes and rapamycin-induced MNK-eIF4E signaling
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Autism"
DOI: 10.1186/s13229-019-0311-3
Abstract: BackgroundTuberous sclerosis complex (TSC) is a neurodevelopmental disorder with frequent occurrence of epilepsy, autism spectrum disorder (ASD), intellectual disability (ID), and tumors in multiple organs. The aberrant activation of mTORC1 in TSC has led to… read more here.
Keywords: mnk; het; eif4e; het null ... See more keywords
A phase 1 dose escalation study of eFT508, an inhibitor of mitogen-activated protein kinase-interacting serine/threonine kinase-1 (MNK-1) and MNK-2 in patients with advanced solid tumors.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2017.35.15_suppl.2579
Abstract: 2579Background: Dysregulated translation of messenger RNA (mRNA) plays a role in the pathogenesis of multiple solid tumors. eFT508, a potent and highly selective small molecule inhibitor of MNK-1 a... read more here.
Keywords: mnk; inhibitor; solid tumors; dose escalation ... See more keywords
Abnormal Development of Neural Stem Cell Niche in the Dentate Gyrus of Menkes Disease
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Stem Cells"
DOI: 10.15283/ijsc21088
Abstract: Background and Objectives Menkes disease (MNK) is a rare X-linked recessive disease, caused by mutations in the copper transporting ATP7A gene that is required for copper homeostasis. MNK patients experience various clinical symptoms including neurological… read more here.
Keywords: mnk; neural stem; dentate gyrus; stem ... See more keywords