Progress in developing MNK inhibitors.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2021.113420
Abstract: The MNKs (mitogen-activated protein kinase-interacting protein kinases) phosphorylate eIF4E (eukaryotic initiation factor 4 E) at serine 209; eIF4E plays an important role in the translation of cytoplasmic mRNAs, all of which possess a 5' 'cap' structure… read more here.
Keywords: mnk; developing mnk; chemistry; progress developing ... See more keywords
MNK Proteins as Therapeutic Targets in Leukemia
Sign Up to like & getrecommendations! Published in 2023 at "OncoTargets and Therapy"
DOI: 10.2147/ott.s370874
Abstract: Abstract In leukemia, resistance to therapy is a major concern for survival. MAPK-interacting kinases (MNKs) have been identified as important activators of oncogenic-related signaling and may be mediators of resistance. Recent studies in leukemia models,… read more here.
Keywords: proteins therapeutic; mnk proteins; mnk inhibitors; targets leukemia ... See more keywords