MNK1 and MNK2 enforce expression of E2F1, FOXM1, and WEE1 to drive soft tissue sarcoma
Sign Up to like & getrecommendations! Published in 2021 at "Oncogene"
DOI: 10.1038/s41388-021-01661-4
Abstract: Soft tissue sarcoma (STS) is a heterogeneous disease that arises from connective tissues. Clinical outcome of patients with advanced tumors especially de-differentiated liposarcoma and uterine leiomyosarcoma remains unsatisfactory, despite intensive treatment regimens including maximal surgical… read more here.
Keywords: sarcoma; tissue sarcoma; soft tissue; mnk1 ... See more keywords
Mitogen-activated protein kinase-interacting kinase 1 is involved in mTOR-mediated pancreatic exocrine function of bovine pancreatic acinar cells with leucine supply.
Sign Up to like & getrecommendations! Published in 2023 at "Archives of animal nutrition"
DOI: 10.1080/1745039x.2023.2199839
Abstract: ABSTRACT Leucine improves the exocrine capacity of the cow pancreas, but the mechanism was not revealed clearly. Mitogen-activated protein kinase-interacting kinase 1 (MNK1) is a pancreatic acinar cell-specific stress response kinase that regulates digestive enzyme… read more here.
Keywords: mnk1; exocrine function; kinase; pancreatic exocrine ... See more keywords
Abstract LB235: Mechanistic studies on VNLG-152R-mediated tumor inhibition of triple negative breast cancer
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-lb235
Abstract: Introduction: Breast cancer remains a major concern as the second leading cause of cancer-related death in women in the United States and the most frequently diagnosed cancer in women globally. Among all the subtypes, triple… read more here.
Keywords: inhibition; mnk1; degradation; vnlg 152r ... See more keywords
MAPK-interacting kinase 1 (Mnk1) regulates platelet production, activation, and thrombosis.
Sign Up to like & getrecommendations! Published in 2022 at "Blood"
DOI: 10.1182/blood.2022015568
Abstract: The MAPK-interacting kinase (Mnk) family includes Mnk1 and Mnk2, which are phosphorylated and activated in response to extracellular stimuli. Mnk1 contributes to cellular responses by regulating mRNA translation and mRNA translation influences platelet production and… read more here.
Keywords: mnk1 regulates; mnk1; interacting kinase; mapk interacting ... See more keywords