Neuroinflammation detected by TSPO-PET precedes dopaminergic neuronal loss in mnt following BCMA-directed CAR-T therapy: Longitudinal multimodal neuroimaging and biomarker insights
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DOI: 10.1182/blood-2025-4172
Abstract: Background: Ciltacabtagene autoleucel (cilta-cel) targets B-cell maturation antigen (BCMA) in multiple myeloma (MM). Rare, potentially life-threatening late-onset neurotoxicity syndromes associated with BCMA targeting encompass movement and neurocognitive treatment-emergent adverse events (MNTs). Underlying pathomechanisms of this… read more here.
Keywords: bcma; cilta cel; mnt onset; car ... See more keywords