Discovery of novel pyrazoline insecticides.
Sign Up to like & getrecommendations! Published in 2024 at "Pest management science"
DOI: 10.1002/ps.8547
Abstract: BACKGROUND The pyrazoline insecticides, invented by Philips Duphar in the 1970s, provide excellent control of lepidopterans and coleopterans and introduced a novel mode of action (MoA) as sodium-channel-blocking insecticides, but were not commercialized due to… read more here.
Keywords: pyrazoline; environmental fate; discovery novel; moa ... See more keywords
Quantitative weight of evidence to assess confidence in potential modes of action
Sign Up to like & getrecommendations! Published in 2017 at "Regulatory Toxicology and Pharmacology"
DOI: 10.1016/j.yrtph.2017.02.017
Abstract: &NA; The evolved World Health Organization/International Programme on Chemical Safety mode of action (MOA) framework provides a structure for evaluating evidence in pathways of causally linked key events (KE) leading to adverse health effects. Although… read more here.
Keywords: confidence; confidence scoring; hypothesized moas; moa ... See more keywords
Update: Mode of action (MOA) for liver tumors induced by oral exposure to 1,4‐dioxane
Sign Up to like & getrecommendations! Published in 2017 at "Regulatory Toxicology and Pharmacology"
DOI: 10.1016/j.yrtph.2017.02.025
Abstract: ABSTRACT Previous work has shown that the weight of evidence supports the hypothesis that 1,4‐dioxane causes liver tumors in rodents through cytotoxicity and subsequent regenerative hyperplasia. Questions regarding a lack of concordant findings for this… read more here.
Keywords: liver; liver tumors; dioxane; moa ... See more keywords
Genetic evidence for post-glacial expansion from a southern refugium in the eastern moa (Emeus crassus)
Sign Up to like & getrecommendations! Published in 2022 at "Biology Letters"
DOI: 10.1098/rsbl.2022.0013
Abstract: Cycles of glacial expansion and contraction throughout the Pleistocene drove increases and decreases, respectively, in the geographical range and population size of many animal species. Genetic data have revealed that during glacial maxima the distribution… read more here.
Keywords: emeus crassus; moa emeus; moa; eastern moa ... See more keywords
Reversible and Irreversible Inhibition of Cytochrome P450 Enzymes by Methylophiopogonanone A
Sign Up to like & getrecommendations! Published in 2020 at "Drug Metabolism and Disposition"
DOI: 10.1124/dmd.120.000325
Abstract: Methylophiopogonanone A (MOA), an abundant homoisoflavonoid bearing a methylenedioxyphenyl moiety, is one of the major constituents in the Chinese herb Ophiopogon japonicas. This work aims to assess the inhibitory potentials of MOA against cytochrome P450… read more here.
Keywords: cyp1a 2c8; inhibition; moa; cytochrome p450 ... See more keywords
Leakage Current Sensor and Neural Network for MOA Monitoring
Sign Up to like & getrecommendations! Published in 2022 at "Computational Intelligence and Neuroscience"
DOI: 10.1155/2022/6728900
Abstract: Metal-oxide arrester (MOA) has been widely used in electric power systems. The leakage current monitoring of MOA can not only detect the MOA's running state continuously and intelligently but also reduce the unexpected outage of… read more here.
Keywords: neural network; leakage current; moa; current sensor ... See more keywords
HoloMoA: a holography and deep learning tool for the identification of antimicrobial mechanisms of action and the detection of novel MoA
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2025.1640252
Abstract: We propose an innovative technology to classify the Mechanism of Action (MoA) of antimicrobials and predict their novelty, called HoloMoA. Our rapid, robust, affordable and versatile tool is based on the combination of time-lapse Digital… read more here.
Keywords: deep learning; tool; moa; action ... See more keywords