Quantitative weight of evidence to assess confidence in potential modes of action
Sign Up to like & getrecommendations! Published in 2017 at "Regulatory Toxicology and Pharmacology"
DOI: 10.1016/j.yrtph.2017.02.017
Abstract: &NA; The evolved World Health Organization/International Programme on Chemical Safety mode of action (MOA) framework provides a structure for evaluating evidence in pathways of causally linked key events (KE) leading to adverse health effects. Although… read more here.
Keywords: confidence; confidence scoring; hypothesized moas; moa ... See more keywords
Update: Mode of action (MOA) for liver tumors induced by oral exposure to 1,4‐dioxane
Sign Up to like & getrecommendations! Published in 2017 at "Regulatory Toxicology and Pharmacology"
DOI: 10.1016/j.yrtph.2017.02.025
Abstract: ABSTRACT Previous work has shown that the weight of evidence supports the hypothesis that 1,4‐dioxane causes liver tumors in rodents through cytotoxicity and subsequent regenerative hyperplasia. Questions regarding a lack of concordant findings for this… read more here.
Keywords: liver; liver tumors; dioxane; moa ... See more keywords
Genetic evidence for post-glacial expansion from a southern refugium in the eastern moa (Emeus crassus)
Sign Up to like & getrecommendations! Published in 2022 at "Biology Letters"
DOI: 10.1098/rsbl.2022.0013
Abstract: Cycles of glacial expansion and contraction throughout the Pleistocene drove increases and decreases, respectively, in the geographical range and population size of many animal species. Genetic data have revealed that during glacial maxima the distribution… read more here.
Keywords: emeus crassus; moa emeus; moa; eastern moa ... See more keywords
Reversible and Irreversible Inhibition of Cytochrome P450 Enzymes by Methylophiopogonanone A
Sign Up to like & getrecommendations! Published in 2020 at "Drug Metabolism and Disposition"
DOI: 10.1124/dmd.120.000325
Abstract: Methylophiopogonanone A (MOA), an abundant homoisoflavonoid bearing a methylenedioxyphenyl moiety, is one of the major constituents in the Chinese herb Ophiopogon japonicas. This work aims to assess the inhibitory potentials of MOA against cytochrome P450… read more here.
Keywords: cyp1a 2c8; inhibition; moa; cytochrome p450 ... See more keywords
Leakage Current Sensor and Neural Network for MOA Monitoring
Sign Up to like & getrecommendations! Published in 2022 at "Computational Intelligence and Neuroscience"
DOI: 10.1155/2022/6728900
Abstract: Metal-oxide arrester (MOA) has been widely used in electric power systems. The leakage current monitoring of MOA can not only detect the MOA's running state continuously and intelligently but also reduce the unexpected outage of… read more here.
Keywords: neural network; leakage current; moa; current sensor ... See more keywords