Circulating cell‐free high mobility group AT‐hook 2 mRNA as a detection marker in the serum of colorectal cancer patients
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.22332
Abstract: Detection of circulating cell‐free mRNA serves as noninvasive tools for cancer diagnosis. As an oncofetal protein, HMGA2 (high mobility group AT‐hook 2) is upregulated in colorectal cancer (CRC) tissues. However, it is not clear whether… read more here.
Keywords: high mobility; cell free; circulating cell; cancer ... See more keywords
High mobility group box 1 as a biomarker in critically ill patients
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DOI: 10.1002/jcla.22584
Abstract: Extracellular release of high mobility group box 1 (HMGB1) acts as a danger‐associated molecular pattern, thereby “alarming” the immune system and promoting systemic inflammation. We investigated plasma HMGB1 concentrations as a potential diagnostic and prognostic… read more here.
Keywords: mobility group; group box; high mobility;
Tumor-derived high-mobility group box 1 and thymic stromal lymphopoietin are involved in modulating dendritic cells to activate T regulatory cells in a mouse model
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Immunology, Immunotherapy"
DOI: 10.1007/s00262-017-2087-7
Abstract: High-mobility group box 1 (HMGB1) is involved in the tumor-associated activation of regulatory T cells (Treg), but the mechanisms remain unknown. In a mouse tumor model, silencing HMGB1 in tumor cells or inhibiting tumor-derived HMGB1… read more here.
Keywords: derived hmgb1; high mobility; tumor derived; tslp ... See more keywords
Crucial role of high-mobility group box 2 in mouse ovarian follicular development through estrogen receptor beta.
Sign Up to like & getrecommendations! Published in 2022 at "Histochemistry and cell biology"
DOI: 10.1007/s00418-022-02074-4
Abstract: High-mobility group box 2 (HMGB2) is a chromatin-associated protein that is an important regulator of gene transcription, recombination, and repair processes. The functional importance of HMGB2 has been reported in various organs, including the testis,… read more here.
Keywords: mouse; mobility group; role; hmgb2 ... See more keywords
High Mobility Group Box 1 is a novel pathogenic factor and a mechanistic biomarker for epilepsy
Sign Up to like & getrecommendations! Published in 2018 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2017.10.008
Abstract: Approximately 30% of epilepsy patients experience seizures that are not controlled by the available drugs. Moreover, these drugs provide mainly a symptomatic treatment since they do not interfere with the disease's mechanisms. A mechanistic approach… read more here.
Keywords: high mobility; group box; mobility group; brain ... See more keywords
High-mobility group box 1 induces bone destruction associated with advanced oral squamous cancer via RAGE and TLR4.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.07.120
Abstract: Bone destruction of maxillary and mandibular bone by invasive oral squamous cell cancer (OSCC) raises various problems in the management of patients, resulting in poor outcomes and survival. However, the mechanism behind bone destruction by… read more here.
Keywords: high mobility; oral squamous; destruction; mobility group ... See more keywords
Serum high-mobility group box 1 protein level correlates with the lowest SaO2 in patients with sleep apnea: a preliminary study.
Sign Up to like & getrecommendations! Published in 2021 at "Brazilian journal of otorhinolaryngology"
DOI: 10.1016/j.bjorl.2020.11.019
Abstract: INTRODUCTION Serum level of high-mobility group box 1 protein is reportedly correlated with the severity of obstructive sleep apnea. OBJECTIVE We tried to evaluate the possibility of using the serum high-mobility group box 1 protein… read more here.
Keywords: sleep apnea; high mobility; mobility group;
Histidine-Rich Glycoprotein Inhibits High-Mobility Group Box-1-Mediated Pathways in Vascular Endothelial Cells through CLEC-1A
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DOI: 10.1016/j.isci.2020.101180
Abstract: Summary High-mobility group box-1 (HMGB1) protein has been postulated to play a pathogenic role in severe sepsis. Histidine-rich glycoprotein (HRG), a 75 kDa plasma protein, was demonstrated to improve the survival rate of septic mice… read more here.
Keywords: hmgb1; high mobility; group box; endothelial cells ... See more keywords
High-mobility group box 1 protein (HMGB1) operates as an alarmin outside as well as inside cells.
Sign Up to like & getrecommendations! Published in 2018 at "Seminars in immunology"
DOI: 10.1016/j.smim.2018.02.011
Abstract: Alarmins are preformed, endogenous molecules that can be promptly released to signal cell or tissue stress or damage. The ubiquitous nuclear molecule high-mobility group box 1 protein (HMGB1) is a prototypical alarmin activating innate immunity.… read more here.
Keywords: hmgb1; protein; high mobility; group box ... See more keywords
High-mobility group nucleosome binding domain 1 (HMGN1) functions as a Th1-polarizing alarmin.
Sign Up to like & getrecommendations! Published in 2018 at "Seminars in immunology"
DOI: 10.1016/j.smim.2018.02.012
Abstract: High-mobility group (HMG) nucleosome binding domain 1 (HMGN1), which previously was thought to function only as a nucleosome-binding protein that regulates chromatin structure, histone modifications, and gene expression, was recently discovered to be an alarmin… read more here.
Keywords: binding domain; high mobility; nucleosome binding; mobility group ... See more keywords
The utility of high-mobility group A2 overexpression for predicting the prognosis of gastric cancer patients and its contribution to poor prognosis via chemoresistance and the propensity for the occurrence of carcinomatosis peritonei.
Sign Up to like & getrecommendations! Published in 2020 at "Surgery"
DOI: 10.1016/j.surg.2020.11.020
Abstract: BACKGROUND The aim of this study was to elucidate the correlation of high-mobility group protein A2 overexpression with gastric cancer prognosis and compare its prognostic power with that of pre-existing markers. METHODS Malignant tissues from… read more here.
Keywords: high mobility; prognosis; group protein; group ... See more keywords