The Use of LipidIMMS Analyzer for Lipid Identification in Ion Mobility-Mass Spectrometry-Based Untargeted Lipidomics.
Sign Up to like & getrecommendations! Published in 2020 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0030-6_17
Abstract: Untargeted lipidomics aims to comprehensively measure and characterize all lipid species in biological systems. Ion mobility-mass spectrometry (IM-MS) has showed a great potential for untargeted lipidomic analysis. Coupling with liquid chromatography and data-independent tandem MS… read more here.
Keywords: lipid identification; mobility mass; ion mobility; ion ... See more keywords
Untargeted Differential Metabolomics Analysis Using Drift Tube Ion Mobility-Mass Spectrometry.
Sign Up to like & getrecommendations! Published in 2020 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0030-6_3
Abstract: Mass spectrometry-based metabolomics is being increasingly applied to a number of applications, including the fields of clinical, industrial, plant, and nutritional science. Several improvements have advanced the field considerably over the past decade, including ultra-high… read more here.
Keywords: mass spectrometry; drift tube; mass; mobility mass ... See more keywords
Isomeric and Conformational Analysis of Small Drug and Drug-Like Molecules by Ion Mobility-Mass Spectrometry (IM-MS).
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9089-4_9
Abstract: This chapter provides a broad overview of ion mobility-mass spectrometry (IM-MS) and its applications in separation science, with a focus on pharmaceutical applications. A general overview of fundamental ion mobility (IM) theory is provided with… read more here.
Keywords: drug; ion mobility; mass spectrometry; mobility mass ... See more keywords
Determination of drugs and drug metabolites by ion mobility-mass spectrometry: A review.
Sign Up to like & getrecommendations! Published in 2021 at "Analytica chimica acta"
DOI: 10.1016/j.aca.2021.338270
Abstract: Ion mobility-mass spectrometry (IM-MS) has gained increased applications in the characterization and identification of drugs and drug metabolites, largely owning to the complementary separation of analyte ions based on their gas-phase size and shape in… read more here.
Keywords: mass spectrometry; drug metabolites; mobility mass; drug ... See more keywords
Technical note: A corrected two dimensional data inversion routine for tandem mobility-mass measurements
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Aerosol Science"
DOI: 10.1016/j.jaerosci.2017.09.012
Abstract: Abstract Tandem mobility and mass measurements of aerosol particles, performed with a differential mobility analyzer-aerosol particle mass analyzer-condensation particle counter (DMA-APM-CPC) or DMA-centrifugal particle mass analyzer-CPC, find increasing application in the analysis of combustion derived… read more here.
Keywords: mobility; mass; two dimensional; mobility mass ... See more keywords
Ion mobility-mass spectrometry and orthogonal gas-phase techniques to study amyloid formation and inhibition.
Sign Up to like & getrecommendations! Published in 2017 at "Current opinion in structural biology"
DOI: 10.1016/j.sbi.2017.03.002
Abstract: Amyloidogenic peptide oligomers are responsible for a variety of neurodegenerative disorders such as Alzheimer's and Parkinson's disease. Due to their dynamic, polydisperse, and polymorphic nature, these oligomers are very challenging to characterize using traditional condensed-phase… read more here.
Keywords: phase; mass spectrometry; mass; mobility mass ... See more keywords
Native Ion Mobility-Mass Spectrometry-Enabled Fast Structural Interrogation of Labile Protein Surface Modifications at the Intact Protein Level.
Sign Up to like & getrecommendations! Published in 2022 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.1c04503
Abstract: Protein sialylation has been closely linked to many diseases including Alzheimer's disease (AD). It is also broadly implicated in therapeutics operating in a pattern-dependent (e.g., Neu5Ac vs Neu5Gc) manner. However, how the sialylation pattern affects… read more here.
Keywords: mass spectrometry; sialylation; fast structural; native ion ... See more keywords
Exploiting Self-Association to Evaluate Enantiomeric Composition by Cyclic Ion Mobility–Mass Spectrometry
Sign Up to like & getrecommendations! Published in 2022 at "Analytical Chemistry"
DOI: 10.1021/acs.analchem.2c01212
Abstract: The characterization of enantiomers is an important analytical challenge in the chemical and life sciences. Thorough evaluation of the purity of chiral molecules is particularly required in the pharmaceutical industry where safety concerns are paramount.… read more here.
Keywords: mobility; composition; cyclic ion; mobility mass ... See more keywords
Top-"Double-Down" Mass Spectrometry of Histone H4 Proteoforms: Tandem Ultraviolet-Photon and Mobility/Mass-Selected Electron Capture Dissociations.
Sign Up to like & getrecommendations! Published in 2022 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.2c03147
Abstract: Post-translational modifications (PTMs) on intact histones play a major role in regulating chromatin dynamics and influence biological processes such as DNA transcription, replication, and repair. The nature and position of each histone PTM is crucial… read more here.
Keywords: histone; top double; ecd; mobility mass ... See more keywords
Ion Mobility-Mass Spectrometry and Collision-Induced Unfolding of Designed Bispecific Antibody Therapeutics.
Sign Up to like & getrecommendations! Published in 2023 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.3c00344
Abstract: Bispecific antibodies (bsAbs) represent a critically important class of emerging therapeutics capable of targeting two different antigens simultaneously. As such, bsAbs have been developed as effective treatment agents for diseases that remain challenging for conventional… read more here.
Keywords: mass spectrometry; kih bsab; mobility mass; ion mobility ... See more keywords
An Interlaboratory Evaluation of Drift Tube Ion Mobility-Mass Spectrometry Collision Cross Section Measurements.
Sign Up to like & getrecommendations! Published in 2017 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.7b01729
Abstract: Collision cross section (CCS) measurements resulting from ion mobility-mass spectrometry (IM-MS) experiments provide a promising orthogonal dimension of structural information in MS-based analytical separations. As with any molecular identifier, interlaboratory standardization must precede broad range… read more here.
Keywords: drift tube; ion mobility; ion; mobility mass ... See more keywords