S-Sulfocysteine Induces Seizure-Like Behaviors in Zebrafish
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2019.00122
Abstract: Sulfite is a neurotoxin, which is detoxified by the molybdenum cofactor (Moco)-dependent enzyme sulfite oxidase (SOX). In humans, SOX deficiency causes the formation of the glutamate analog S-Sulfocysteine (SSC) resulting in a constant overstimulation of… read more here.
Keywords: seizure like; sox deficiency; sulfocysteine induces; induces seizure ... See more keywords
The Human Mercaptopyruvate Sulfurtransferase TUM1 Is Involved in Moco Biosynthesis, Cytosolic tRNA Thiolation and Cellular Bioenergetics in Human Embryonic Kidney Cells
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DOI: 10.3390/biom13010144
Abstract: Sulfur is an important element that is incorporated into many biomolecules in humans. The incorporation and transfer of sulfur into biomolecules is, however, facilitated by a series of different sulfurtransferases. Among these sulfurtransferases is the… read more here.
Keywords: biosynthesis; human mercaptopyruvate; mercaptopyruvate sulfurtransferase; moco biosynthesis ... See more keywords
Physiological Importance of Molybdate Transporter Family 1 in Feeding the Molybdenum Cofactor Biosynthesis Pathway in Arabidopsis thaliana
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DOI: 10.3390/molecules27103158
Abstract: Molybdate uptake and molybdenum cofactor (Moco) biosynthesis were investigated in detail in the last few decades. The present study critically reviews our present knowledge about eukaryotic molybdate transporters (MOT) and focuses on the model plant… read more here.
Keywords: biosynthesis; molybdenum cofactor; molybdate; moco biosynthesis ... See more keywords
Beyond Moco Biosynthesis―Moonlighting Roles of MoaE and MOCS2
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DOI: 10.3390/molecules27123733
Abstract: Molybdenum cofactor (Moco) biosynthesis requires iron, copper, and ATP. The Moco-containing enzyme sulfite oxidase catalyzes terminal oxidation in oxidative cysteine catabolism, and another Moco-containing enzyme, xanthine dehydrogenase, functions in purine catabolism. Thus, molybdenum enzymes participate… read more here.
Keywords: beyond moco; biosynthesis; biosynthesis moonlighting; roles moae ... See more keywords