LAUSR

Mod(mdg4) variants repress telomeric retrotransposon HeT-A by blocking subtelomeric enhancers

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1 Published in 2022 at "Nucleic Acids Research"

DOI: 10.1093/nar/gkac1034

Abstract: Telomeres in Drosophila are composed of sequential non-LTR retrotransposons: HeT-A, TART, and TAHRE. Although they are repressed by the piRNA pathway in the germline, how these retrotransposons are regulated in somatic cells is poorly understood.… read more here.

Keywords: het; subtelomeric enhancers; het blocking; blocking subtelomeric ... See more keywords

Studying Interactions between the Mod(mdg4)-67.2 Protein and Other Mod(mdg4) Isoforms in the Embryonic Cells of Drosophila melanogaster

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1 Published in 2019 at "Doklady Biochemistry and Biophysics"

DOI: 10.1134/s1607672919030049

Abstract: It is found that, in embryonic D. melanogaster cells, Mod(mdg4) protein isoforms can interact with each other through BTB domains. However, this nonspecific interaction is destroyed as a result of recruitment of protein complexes to… read more here.

Keywords: mod mdg4; mdg4 protein; studying interactions; interactions mod ... See more keywords

Role of Su(Hw) zinc finger 10 and interaction with CP190 and Mod(mdg4) proteins in recruiting the Su(Hw) complex to chromatin sites in Drosophila

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1 Published in 2018 at "PLoS ONE"

DOI: 10.1371/journal.pone.0193497

Abstract: Su(Hw) belongs to the class of proteins that organize chromosome architecture and boundaries/insulators between regulatory domains. This protein contains a cluster of 12 zinc finger domains most of which are responsible for binding to three… read more here.

Keywords: zinc finger; cp190 mod; mod mdg4; cp190 ... See more keywords

Drosophila SUMM4 complex couples insulator function and DNA replication control

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1 Published in 2022 at "eLife"

DOI: 10.7554/elife.81828

Abstract: Asynchronous replication of chromosome domains during S phase is essential for eukaryotic genome function, but the mechanisms establishing which domains replicate early versus late in different cell types remain incompletely understood. Intercalary heterochromatin domains replicate… read more here.

Keywords: replication control; replication; insulator function; mod mdg4 ... See more keywords