A closer look at the mode of binding of drug pemetrexed with CT-DNA
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2022.2051747
Abstract: Abstract The interaction of antifolate drug Pemetrexed (PEM) with CT-DNA has been studied by UV-Vis, fluorescence and circular dichroism spectroscopic techniques. The results of these spectroscopic studies in combination with viscosity measurements, voltammetric and KI… read more here.
Keywords: dna; mode binding; closer look; pem dna ... See more keywords
Systemic CLIP-seq analysis and game theory approach to model microRNA mode of binding
Sign Up to like & getrecommendations! Published in 2021 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkab198
Abstract: Abstract microRNAs (miRNAs) associate with Ago proteins to post-transcriptionally silence gene expression by targeting mRNAs. To characterize the modes of miRNA-binding, we developed a novel computational framework, called optiCLIP, which considers the reproducibility of the… read more here.
Keywords: clip seq; mode binding; mirna binding; binding sites ... See more keywords