Mechanistic modeling, simulation, and optimization of mixed‐mode chromatography for an antibody polishing step
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology Progress"
DOI: 10.1002/btpr.3316
Abstract: Mixed‐mode chromatography combines features of ion‐exchange chromatography and hydrophobic interaction chromatography and is increasingly used in antibody purification. As a replacement for flow‐through operations on traditional unmixed resins or as a pH‐controlled bind‐and‐elute step, the… read more here.
Keywords: step; mode chromatography; process; mixed mode ... See more keywords
Mixed-Mode Chromatography: Studies on Hybrid Retention Mechanisms of Some Antihypertensive Drugs
Sign Up to like & getrecommendations! Published in 2025 at "Separations"
DOI: 10.3390/separations12060136
Abstract: The antihypertensive drugs indapamide, atenolol, metoprolol, propranolol and bisoprolol were considered in this research. Because they have structures that are affected by pH, developing a chromatographic method was challenging. Based on the speciation diagram of… read more here.
Keywords: antihypertensive drugs; mixed mode; retention; mode chromatography ... See more keywords