A semiphysiological population pharmacokinetic model of agomelatine and its metabolites in Chinese healthy volunteers
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DOI: 10.1111/bcp.13902
Abstract: Agomelatine is an antidepressant for major depressive disorders. It undergoes extensive first‐pass hepatic metabolism and displays irregular absorption profiles and large interindividual variability (IIV) and interoccasion variability of pharmacokinetics. The objective of this study was… read more here.
Keywords: pharmacokinetic model; population pharmacokinetic; model agomelatine; semiphysiological population ... See more keywords