Bowman‐Birk inhibitor modifies transcription of autophagy and apoptosis genes in an in vitro model of Alzheimer's disorder
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.28391
Abstract: Alzheimer, a current neurodegenerative disorder has adverse effects on memory and behavior. β‐Amyloid peptide accumulations are the hallmarks of Alzheimer. Dysfunction of autophagy and apoptosis is detected in Alzheimer's disease. The effect of Bowman‐Birk inhibitor… read more here.
Keywords: autophagy apoptosis; model alzheimer; vitro model; birk inhibitor ... See more keywords
Longitudinal assessment of cerebral perfusion and vascular response to hypoventilation in a bigenic mouse model of Alzheimer's disease with amyloid and tau pathology
Sign Up to like & getrecommendations! Published in 2019 at "NMR in Biomedicine"
DOI: 10.1002/nbm.4037
Abstract: Alzheimer's disease is the most common neurodegenerative disease, and many patients also present with vascular dysfunction. In this study, we aimed to assess cerebral blood flow (CBF) and cerebrovascular response (CVR) as early, pre‐symptomatic (3… read more here.
Keywords: model alzheimer; perfusion; alzheimer disease; disease ... See more keywords
Longitudinal MRI Characterization of T 1 and T 2 Relaxation Times in an Amyloid Mouse Model of Alzheimer's Disease at 11.7 T
Sign Up to like & getrecommendations! Published in 2025 at "Nmr in Biomedicine"
DOI: 10.1002/nbm.70187
Abstract: Longitudinal (T1) and transverse (T2) relaxation times measured by MRI are promising markers for assessing biological processes and disease pathology. In this study, we characterized the T1 and T2 relaxation times in the Tg2576 mouse… read more here.
Keywords: alzheimer disease; mouse model; relaxation; model alzheimer ... See more keywords
Fibre supplementation alters the gastrointestinal microbiome, the microbial metabolites and indicators of neurodegeneration in a mouse model of Alzheimer´s disease
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-20986-8
Abstract: Alzheimer´s disease is a neurodegenerative disease with high global prevalence and no cure available. It is known that the microbiota-gut-brain-axis plays a role in the pathogenesis, but the pathways are not fully understood yet. To… read more here.
Keywords: supplementation; alzheimer disease; disease; fibre supplementation ... See more keywords
Neuroprotective properties of solanum leaves in transgenic Drosophila melanogaster model of Alzheimer's disease
Sign Up to like & getrecommendations! Published in 2022 at "Biomarkers"
DOI: 10.1080/1354750x.2022.2077446
Abstract: Abstract Introduction We investigated the effect of African eggplant (AE) (Solanum macrocarpon L) and Black nightshade (BN) (Solanum nigrum L) leaves; two tropical vegetables consumed by humans on behavioural, biochemical and histological indices in Drosophila… read more here.
Keywords: model alzheimer; alzheimer disease; neuroprotective properties; melanogaster model ... See more keywords
Electrophysiological alterations of the Purkinje cells and deep cerebellar neurons in a mouse model of Alzheimer disease (electrophysiology on cerebellum of AD mice)
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Neuroscience"
DOI: 10.1111/ejn.15621
Abstract: Alzheimer's disease is histopathologically well defined by the presence of amyloid deposits and tau‐related neurofibrillary tangles in crucial regions of the brain. Interest is growing in revealing and determining possible pathological markers also in the… read more here.
Keywords: model alzheimer; electrophysiological alterations; disease; alzheimer disease ... See more keywords
URMC-099 facilitates amyloid-β clearance in a murine model of Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Neuroinflammation"
DOI: 10.1186/s12974-018-1172-y
Abstract: BackgroundThe mixed lineage kinase type 3 inhibitor URMC-099 facilitates amyloid-beta (Aβ) clearance and degradation in cultured murine microglia. One putative mechanism is an effect of URMC-099 on Aβ uptake and degradation. As URMC-099 promotes endolysosomal protein… read more here.
Keywords: model alzheimer; urmc 099; facilitates amyloid; 099 facilitates ... See more keywords
Meridianins Rescue Cognitive Deficits, Spine Density and Neuroinflammation in the 5xFAD Model of Alzheimer’s Disease
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.791666
Abstract: Glycogen synthase kinase 3β (GSK3β) is a core protein, with a relevant role in many neurodegenerative disorders including Alzheimer’s disease. The enzyme has been largely studied as a potential therapeutic target for several neurological diseases.… read more here.
Keywords: model alzheimer; disease; alzheimer disease; meridianins rescue ... See more keywords
5-Methyltetrahydrofolate Alleviates Memory Impairment in a Rat Model of Alzheimer’s Disease Induced by D-Galactose and Aluminum Chloride
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Environmental Research and Public Health"
DOI: 10.3390/ijerph192416426
Abstract: The effects of 5-methyltetrahydrofolate (5-MTHF) on a rat model of Alzheimer’s disease (AD) induced by D-galactose (D-gal) and aluminum chloride (AlCl3) were investigated. Wistar rats were given an i.p. injection of 60 mg/kg D-gal and… read more here.
Keywords: model alzheimer; rat; alzheimer disease; disease induced ... See more keywords
Revisiting the Radiosynthesis of [18F]FPEB and Preliminary PET Imaging in a Mouse Model of Alzheimer’s Disease
Sign Up to like & getrecommendations! Published in 2020 at "Molecules"
DOI: 10.3390/molecules25040982
Abstract: [18F]FPEB is a positron emission tomography (PET) radiopharmaceutical used for imaging the abundance and distribution of mGluR5 in the central nervous system (CNS). Efficient radiolabeling of the aromatic ring of [18F]FPEB has been an ongoing… read more here.
Keywords: 18f fpeb; model alzheimer; alzheimer disease; preliminary pet ... See more keywords
Alimentary Treatment with Trehalose in a Pharmacological Model of Alzheimer’s Disease in Mice: Effects of Different Dosages and Treatment Regimens
Sign Up to like & getrecommendations! Published in 2024 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics16060813
Abstract: In the treatment of experimental neurodegeneration with disaccharide trehalose, various regimens are used, predominantly a 2% solution, drunk for several weeks. We studied the effects of different regimens of dietary trehalose treatment in an amyloid-β… read more here.
Keywords: model alzheimer; treatment; effects different; alzheimer disease ... See more keywords