Fingolimod (FTY720) attenuates social deficits, learning and memory impairments, neuronal loss and neuroinflammation in the rat model of autism
Sign Up to like & getrecommendations! Published in 2017 at "Life Sciences"
DOI: 10.1016/j.lfs.2017.01.012
Abstract: Aims: To investigate the effect of FTY720 on the valproic acid (VPA) rat model of autism. Main methods: As an animal model of autism, we used intraperitoneal injection of VPA on embryonic day 12.5 in… read more here.
Keywords: model autism; memory; learning memory; fty720 ... See more keywords
UPR activation specifically modulates glutamate neurotransmission in the cerebellum of a mouse model of autism
Sign Up to like & getrecommendations! Published in 2018 at "Neurobiology of Disease"
DOI: 10.1016/j.nbd.2018.08.026
Abstract: An increasing number of rare mutations linked to autism spectrum disorders have been reported in genes encoding for proteins involved in synapse formation and maintenance, such as the post-synaptic cell adhesion proteins neuroligins. Most of… read more here.
Keywords: model autism; autism; mouse model; activation ... See more keywords
Effects of single-dose antipurinergic therapy on behavioral and molecular alterations in the valproic acid-induced animal model of autism
Sign Up to like & getrecommendations! Published in 2020 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2019.107930
Abstract: Autism spectrum disorder (ASD) is characterized by deficits in communication and social interaction, restricted interests, and stereotyped behavior. Environmental factors, such as prenatal exposure to valproic acid (VPA), may contribute to the increased risk of… read more here.
Keywords: animal model; model autism; autism; valproic acid ... See more keywords
Embryonic stem cell transplants as a therapeutic strategy in a rodent model of autism
Sign Up to like & getrecommendations! Published in 2018 at "Neuropsychopharmacology"
DOI: 10.1038/s41386-018-0021-0
Abstract: Autism is a neurodevelopmental disorder characterized by disruptions in three core behavioral domains: deficits in social interaction, impairments in communication, and repetitive and stereotyped patterns of behavior or thought. There are currently no drugs available… read more here.
Keywords: model autism; autism; stem cell; rodent model ... See more keywords
TCHis mitigate oxidative stress and improve abnormal behavior in a prenatal valproic acid-exposed rat model of autism.
Sign Up to like & getrecommendations! Published in 2022 at "Physiological genomics"
DOI: 10.1152/physiolgenomics.00104.2021
Abstract: Objective Troxerutin is known for its anti-inflammatory and antioxidative effects in nerve impairment. The purpose of this study is to investigate the effect of troxerutin and cerebroprotein hydrolysate injections (TCHis) on prenatal valproic acid (VPA)-exposed… read more here.
Keywords: model autism; vpa; oxidative stress; tchis ... See more keywords
Exosomes derived from mesenchymal stem cells improved core symptoms of genetically modified mouse model of autism Shank3B
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Autism"
DOI: 10.1186/s13229-020-00366-x
Abstract: Background Partial or an entire deletion of SHANK3 are considered as major drivers in the Phelan–McDermid syndrome, in which 75% of patients are diagnosed with autism spectrum disorder (ASD). During the recent years, there was… read more here.
Keywords: model autism; autism; msc; stem ... See more keywords
Acute rapamycin rescues the hyperexcitable phenotype of accumbal medium spiny neurons in the valproic acid rat model of autism spectrum disorder.
Sign Up to like & getrecommendations! Published in 2022 at "Pharmacological research"
DOI: 10.2139/ssrn.4132997
Abstract: We previously demonstrated that prenatal exposure to valproic acid (VPA), an environmental model of autism spectrum disorder (ASD), leads to a hyperexcitable phenotype associated with downregulation of inward-rectifying potassium currents in nucleus accumbens (NAc) medium… read more here.
Keywords: phenotype; model autism; vpa; autism spectrum ... See more keywords
A Developmental Study of Abnormal Behaviors and Altered GABAergic Signaling in the VPA-Treated Rat Model of Autism
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Behavioral Neuroscience"
DOI: 10.3389/fnbeh.2018.00182
Abstract: Although studies have investigated the role of gamma-aminobutyric acid (GABA)ergic signaling in rodent neural development and behaviors relevant to autism, behavioral ontogeny, as underlain by the changes in GABAergic system, is poorly characterized in different… read more here.
Keywords: model autism; autism; gad67 expression; expression ... See more keywords
Altered expression of glycan patterns and glycan-related genes in the medial prefrontal cortex of the valproic acid rat model of autism
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2022.1057857
Abstract: Autism spectrum disorders (ASD) represent a group of neurodevelopmental defects characterized by social deficits and repetitive behaviors. Alteration in Glycosylation patterns could influence the nervous system development and contribute to the molecular mechanism of ASD.… read more here.
Keywords: model autism; glycan patterns; glycan related; valproic acid ... See more keywords
Resveratrol Prevents Cellular and Behavioral Sensory Alterations in the Animal Model of Autism Induced by Valproic Acid
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Synaptic Neuroscience"
DOI: 10.3389/fnsyn.2018.00009
Abstract: Autism spectrum disorder (ASD) is characterized by impairments in both social communication and interaction and repetitive or stereotyped behaviors. Although its etiology remains unknown, genetic and environmental risk factors have been associated with this disorder,… read more here.
Keywords: model autism; autism; valproic acid; animal model ... See more keywords