DVH analysis using a transmission detector and model‐based dose verification system as a comprehensive pretreatment QA tool for VMAT plans: Clinical experience and results
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Applied Clinical Medical Physics"
DOI: 10.1002/acm2.12743
Abstract: Abstract Purpose Dose volume histogram (DVH)‐based analysis is utilized as a pretreatment quality assurance tool to determine clinical relevance from measured dose which is difficult in conventional gamma‐based analysis. In this study, we report our… read more here.
Keywords: dvh analysis; model based; analysis; verification system ... See more keywords
A Study of Model‐Based Protective Fast‐Charging and Associated Degradation in Commercial Smartphone Cells: Insights on Cathode Degradation as a Result of Lithium Depositions on the Anode
Sign Up to like & getrecommendations! Published in 2021 at "Advanced Energy Materials"
DOI: 10.1002/aenm.202003019
Abstract: The ever expanding mobile consumer electronic market has accelerated the need for safe and efficient fast‐charging approaches that improve the overall speed of battery charging without hastened deterioration of the battery performance. Herein, the impact… read more here.
Keywords: model based; degradation; lithium; based protective ... See more keywords
Optimal model‐based control of non‐viral siRNA delivery
Sign Up to like & getrecommendations! Published in 2018 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.26596
Abstract: Further quantitative understanding of the biological effects and mechanisms involved in cellular and intracellular delivery of nucleic acid materials is required to produce clinical applications of gene therapy. Several modeling approaches have been used in… read more here.
Keywords: model based; non viral; viral sirna; delivery ... See more keywords
Model‐based monitoring of industrial reversed phase chromatography to predict insulin variants
Sign Up to like & getrecommendations! Published in 2019 at "Biotechnology Progress"
DOI: 10.1002/btpr.2813
Abstract: Downstream processing in the manufacturing biopharmaceutical industry is a multistep process separating the desired product from process‐ and product‐related impurities. However, removing product‐related impurities, such as product variants, without compromising the product yield or prolonging… read more here.
Keywords: model based; based monitoring; insulin variants; product ... See more keywords
A prediction model based on deep learning and radiomics features of DWI for the assessment of microsatellite instability in endometrial cancer
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Medicine"
DOI: 10.1002/cam4.70046
Abstract: To explore the efficacy of a prediction model based on diffusion‐weighted imaging (DWI) features extracted from deep learning (DL) and radiomics combined with clinical parameters and apparent diffusion coefficient (ADC) values to identify microsatellite instability… read more here.
Keywords: deep learning; cancer; model based; learning radiomics ... See more keywords
Model‐Based Meta‐Analysis Compares DAS28 Rheumatoid Arthritis Treatment Effects and Suggests an Expedited Trial Design for Early Clinical Development
Sign Up to like & getrecommendations! Published in 2020 at "Clinical Pharmacology and Therapeutics"
DOI: 10.1002/cpt.2023
Abstract: A nonlinear mixed effects modeling approach was used to conduct a model‐based meta‐analysis (MBMA) of longitudinal, summary‐level, baseline‐corrected 28‐joint Disease Activity Score (ΔDAS28) clinical trial data from seven approved rheumatoid arthritis (RA) drugs (abatacept, adalimumab,… read more here.
Keywords: model based; trial; analysis; treatment ... See more keywords
Leveraging Real‐World Data for EMA Qualification of a Model‐Based Biomarker Tool to Optimize Type‐1 Diabetes Prevention Studies
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Pharmacology and Therapeutics"
DOI: 10.1002/cpt.2559
Abstract: The development of therapies to prevent or delay the onset of type 1 diabetes (T1D) remains challenging, and there is a lack of qualified biomarkers to identify individuals at risk of developing T1D or to… read more here.
Keywords: prevention; type diabetes; model; prevention studies ... See more keywords
Response-Based Dosing for Ponatinib: Model-Based Analyses of the Dose-Ranging OPTIC Study.
Sign Up to like & getrecommendations! Published in 2023 at "Clinical pharmacology and therapeutics"
DOI: 10.1002/cpt.2956
Abstract: OPTIC was a randomized, phase 2 dose-optimization trial of ponatinib in chronic phase-chronic myeloid leukemia (CP-CML) resistant to ≥2 tyrosine kinase inhibitors or with T315I mutation. Patients were randomized to starting doses of 45-, 30-,… read more here.
Keywords: ponatinib; response; dose increase; exposure ... See more keywords
The Contributions of Risk Factor Modifications to the Reduction of Cardiovascular Risk in Patients With Antidiabetic Treatment: A Meta‐Regression Analysis and Model‐Based Analysis
Sign Up to like & getrecommendations! Published in 2025 at "Diabetes/Metabolism Research and Reviews"
DOI: 10.1002/dmrr.70052
Abstract: This meta‐regression analysis and model‐based analysis aimed to assess the contributions of the risk factors and identify the predominant ones. read more here.
Keywords: model based; analysis; regression analysis; meta regression ... See more keywords
A model‐based assessment of anthropogenic disturbance on lotic macroinvertebrate assemblages
Sign Up to like & getrecommendations! Published in 2025 at "Ecosphere"
DOI: 10.1002/ecs2.70361
Abstract: Traditionally, the effects of anthropogenic disturbance on biological assemblages are elucidated by comparing an assemblage observed at a site to one that represents a minimally disturbed state. Unfortunately, defining a minimally disturbed state is extremely… read more here.
Keywords: model based; disturbance; anthropogenic disturbance; macroinvertebrate assemblages ... See more keywords
Diffusion Model‐Based MRI Super‐Resolution Synthesis
Sign Up to like & getrecommendations! Published in 2025 at "International Journal of Imaging Systems and Technology"
DOI: 10.1002/ima.70021
Abstract: In modern medical imaging, although there have been advances in the application of super‐resolution technology to MRI in recent years, current applications still cannot meet practical needs. For example, for MRI images under specific pathological… read more here.
Keywords: diffusion model; resolution; super resolution; model based ... See more keywords