DVH analysis using a transmission detector and model‐based dose verification system as a comprehensive pretreatment QA tool for VMAT plans: Clinical experience and results
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Applied Clinical Medical Physics"
DOI: 10.1002/acm2.12743
Abstract: Abstract Purpose Dose volume histogram (DVH)‐based analysis is utilized as a pretreatment quality assurance tool to determine clinical relevance from measured dose which is difficult in conventional gamma‐based analysis. In this study, we report our… read more here.
Keywords: dvh analysis; model based; analysis; verification system ... See more keywords
A Study of Model‐Based Protective Fast‐Charging and Associated Degradation in Commercial Smartphone Cells: Insights on Cathode Degradation as a Result of Lithium Depositions on the Anode
Sign Up to like & getrecommendations! Published in 2021 at "Advanced Energy Materials"
DOI: 10.1002/aenm.202003019
Abstract: The ever expanding mobile consumer electronic market has accelerated the need for safe and efficient fast‐charging approaches that improve the overall speed of battery charging without hastened deterioration of the battery performance. Herein, the impact… read more here.
Keywords: model based; degradation; lithium; based protective ... See more keywords
Optimal model‐based control of non‐viral siRNA delivery
Sign Up to like & getrecommendations! Published in 2018 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.26596
Abstract: Further quantitative understanding of the biological effects and mechanisms involved in cellular and intracellular delivery of nucleic acid materials is required to produce clinical applications of gene therapy. Several modeling approaches have been used in… read more here.
Keywords: model based; non viral; viral sirna; delivery ... See more keywords
Model‐based monitoring of industrial reversed phase chromatography to predict insulin variants
Sign Up to like & getrecommendations! Published in 2019 at "Biotechnology Progress"
DOI: 10.1002/btpr.2813
Abstract: Downstream processing in the manufacturing biopharmaceutical industry is a multistep process separating the desired product from process‐ and product‐related impurities. However, removing product‐related impurities, such as product variants, without compromising the product yield or prolonging… read more here.
Keywords: model based; based monitoring; insulin variants; product ... See more keywords
Model‐Based Meta‐Analysis Compares DAS28 Rheumatoid Arthritis Treatment Effects and Suggests an Expedited Trial Design for Early Clinical Development
Sign Up to like & getrecommendations! Published in 2020 at "Clinical Pharmacology and Therapeutics"
DOI: 10.1002/cpt.2023
Abstract: A nonlinear mixed effects modeling approach was used to conduct a model‐based meta‐analysis (MBMA) of longitudinal, summary‐level, baseline‐corrected 28‐joint Disease Activity Score (ΔDAS28) clinical trial data from seven approved rheumatoid arthritis (RA) drugs (abatacept, adalimumab,… read more here.
Keywords: model based; trial; analysis; treatment ... See more keywords
Leveraging Real‐World Data for EMA Qualification of a Model‐Based Biomarker Tool to Optimize Type‐1 Diabetes Prevention Studies
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Pharmacology and Therapeutics"
DOI: 10.1002/cpt.2559
Abstract: The development of therapies to prevent or delay the onset of type 1 diabetes (T1D) remains challenging, and there is a lack of qualified biomarkers to identify individuals at risk of developing T1D or to… read more here.
Keywords: prevention; type diabetes; model; prevention studies ... See more keywords
Response-Based Dosing for Ponatinib: Model-Based Analyses of the Dose-Ranging OPTIC Study.
Sign Up to like & getrecommendations! Published in 2023 at "Clinical pharmacology and therapeutics"
DOI: 10.1002/cpt.2956
Abstract: OPTIC was a randomized, phase 2 dose-optimization trial of ponatinib in chronic phase-chronic myeloid leukemia (CP-CML) resistant to ≥2 tyrosine kinase inhibitors or with T315I mutation. Patients were randomized to starting doses of 45-, 30-,… read more here.
Keywords: ponatinib; response; dose increase; exposure ... See more keywords
Beyond backpropagate through time: Efficient model‐based training through time‐splitting
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Intelligent Systems"
DOI: 10.1002/int.22928
Abstract: Model‐based policy gradient (MBPG) has been employed to seek an approximate solution to the optimal control problem. However, there is coupling between adjacent states due to temporal dependencies, making the training time grow linearly with… read more here.
Keywords: training time; time; training; time splitting ... See more keywords
Weighted model‐based optoacoustic reconstruction for partial‐view geometries
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biophotonics"
DOI: 10.1002/jbio.202100334
Abstract: Acoustic heterogeneities in biological samples are known to cause artifacts in tomographic optoacoustic (photoacoustic) image reconstruction. A statistical weighted model‐based reconstruction approach was previously introduced to mitigate such artifacts. However, this approach does not reliably… read more here.
Keywords: view; geometry; weighted model; model based ... See more keywords
Do not forget the children: a model‐based analysis on the potential impact of COVID‐19‐associated interruptions in paediatric HIV prevention and care
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the International AIDS Society"
DOI: 10.1002/jia2.25864
Abstract: The COVID‐19 pandemic has affected women and children globally, disrupting antiretroviral therapy (ART) services and exacerbating pre‐existing barriers to care for both pregnant women and paediatric populations. read more here.
Keywords: analysis potential; potential impact; children model; forget children ... See more keywords
Model‐based dose reconstruction for CT dose estimation
Sign Up to like & getrecommendations! Published in 2017 at "Medical Physics"
DOI: 10.1002/mp.12409
Abstract: Purpose Our goal is to develop a model‐based approach for CT dose estimation. We previously presented a CT dose estimation method that offered good accuracy in soft tissue regions but lower accuracy in bone regions.… read more here.
Keywords: reconstruction; model based; monte carlo; dose estimation ... See more keywords