Perfusion applied to a 3D model of bone metastasis results in uniformly dispersed mechanical stimuli
Sign Up to like & getrecommendations! Published in 2018 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.26524
Abstract: Breast cancer most frequently metastasizes to the skeleton. Bone metastatic cancer is incurable and induces wide‐spread bone osteolysis, resulting in significant patient morbidity and mortality. Mechanical cues in the skeleton are an important microenvironmental parameter… read more here.
Keywords: model bone; perfusion; bone; model ... See more keywords
A cellular automata model of bone formation.
Sign Up to like & getrecommendations! Published in 2017 at "Mathematical biosciences"
DOI: 10.1016/j.mbs.2017.02.001
Abstract: Bone remodeling is an elegantly orchestrated process by which osteocytes, osteoblasts and osteoclasts function as a syncytium to maintain or modify bone. On the microscopic level, bone consists of cells that create, destroy and monitor… read more here.
Keywords: model bone; bone formation; bone; model ... See more keywords
A microphysiological model of bone development and regeneration.
Sign Up to like & getrecommendations! Published in 2023 at "Biofabrication"
DOI: 10.1088/1758-5090/acd6be
Abstract: Endochondral ossification (EO) is an essential biological process than underpins how human bones develop, grow, and heal in the event of a fracture. So much is unknown about this process, thus clinical manifestations of dysregulated… read more here.
Keywords: development; model bone; bone development; microphysiological model ... See more keywords