Epigenetically modified cardiac mesenchymal stromal cells limit myocardial fibrosis and promote functional recovery in a model of chronic ischemic cardiomyopathy
Sign Up to like & getrecommendations! Published in 2018 at "Basic Research in Cardiology"
DOI: 10.1007/s00395-018-0710-1
Abstract: Preclinical investigations support the concept that donor cells more oriented towards a cardiovascular phenotype favor repair. In light of this philosophy, we previously identified HDAC1 as a mediator of cardiac mesenchymal cell (CMC) cardiomyogenic lineage… read more here.
Keywords: ischemic cardiomyopathy; myocardial fibrosis; chronic ischemic; cmc ... See more keywords
Beneficial effects of ursodeoxycholic acid via inhibition of airway remodelling, apoptosis of airway epithelial cells, and Th2 immune response in murine model of chronic asthma.
Sign Up to like & getrecommendations! Published in 2017 at "Allergologia et immunopathologia"
DOI: 10.1016/j.aller.2016.12.003
Abstract: BACKGROUND AND AIMS In previous studies, anti-inflammatory, anti-apoptotic and immunomodulatory effects of ursodeoxycholic acid (UDCA) on liver diseases have been shown. In this study, we aimed to investigate the effects of UDCA on airway remodelling,… read more here.
Keywords: airway remodelling; ursodeoxycholic acid; apoptosis; effects ursodeoxycholic ... See more keywords
Interleukin-6 expression and its modulation by diacerein in a rat model of chronic stress induced cardiac dysfunction
Sign Up to like & getrecommendations! Published in 2021 at "Heliyon"
DOI: 10.1016/j.heliyon.2021.e08522
Abstract: People with chronic stress have higher levels of pro-inflammatory cytokines, which enhance their susceptibility to cardiovascular diseases. Diacerein has ability to modulate pro-inflammatory cytokines such as IL-1β and IL-6; however, its efficacy in chronic stress… read more here.
Keywords: stress; model chronic; rat model; stress induced ... See more keywords
Progressive increase in allergen concentration abrogates immune tolerance in ovalbumin‐induced murine model of chronic asthma
Sign Up to like & getrecommendations! Published in 2018 at "International Immunopharmacology"
DOI: 10.1016/j.intimp.2018.04.047
Abstract: ABSTRACT Persistent inflammation and remodeling of airways are the major hallmarks of asthma. Though airway inflammation diminishes in ovalbumin (OVA)‐based mouse model of chronic asthma owing to immune‐tolerance linked with repeated allergen exposure, which limits… read more here.
Keywords: inflammation; chronic asthma; model; model chronic ... See more keywords
Mesocorticolimbic monoamines in a rodent model of chronic neuropathic pain
Sign Up to like & getrecommendations! Published in 2020 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2020.135309
Abstract: Chronic pain manifests in multiple disorders and is highly debilitating. While its pathophysiology is not fully understood, the involvement of the mesocorticolimbic monoaminergic systems have been shown to play a critical role in chronic pain… read more here.
Keywords: mesocorticolimbic monoamines; monoamines rodent; model chronic; rodent model ... See more keywords
Melatonin improves brain function in a model of chronic Gulf War Illness with modulation of oxidative stress, NLRP3 inflammasomes, and BDNF-ERK-CREB pathway in the hippocampus
Sign Up to like & getrecommendations! Published in 2021 at "Redox Biology"
DOI: 10.1016/j.redox.2021.101973
Abstract: Persistent cognitive and mood dysfunction is the primary CNS symptom in veterans afflicted with Gulf War Illness (GWI). This study investigated the efficacy of melatonin (MEL) for improving cognitive and mood function with antioxidant, antiinflammatory,… read more here.
Keywords: hippocampus; mel; model chronic; cognitive mood ... See more keywords
A Biopsychosocial Model of Chronic Pain for Older Adults.
Sign Up to like & getrecommendations! Published in 2019 at "Pain medicine"
DOI: 10.1093/pm/pnz329
Abstract: POPULATION Comprehensive evaluation of chronic pain in older adults is multifaceted. OBJECTIVE AND METHODS Research on chronic pain in older adults needs to be guided by sound conceptual models. The purpose of this paper is… read more here.
Keywords: model chronic; pain older; older adults; chronic pain ... See more keywords
Triiodothyronine attenuates the progression of renal injury in a rat model of chronic kidney disease
Sign Up to like & getrecommendations! Published in 2018 at "Canadian Journal of Physiology and Pharmacology"
DOI: 10.1139/cjpp-2017-0252
Abstract: This study was designed to investigate whether and how triiodothyronine (T3) affects renal function in an experimental model of chronic kidney disease. Twenty-four female rats were divided into the following groups: sham-operated control group (n… read more here.
Keywords: kidney; chronic kidney; triiodothyronine; group ... See more keywords
A refined and translationally relevant model of chronic DSS colitis in BALB/c mice
Sign Up to like & getrecommendations! Published in 2018 at "Laboratory Animals"
DOI: 10.1177/0023677217742681
Abstract: Inflammatory bowel diseases (IBD) are chronic relapsing disorders of the gastrointestinal tract. Several mouse models for IBD are available, but the acute dextran sulfate sodium (DSS)-induced colitis model is mostly used for preclinical studies. However,… read more here.
Keywords: dss colitis; colitis; model chronic; chronic dss ... See more keywords
Protective effects of blocking PD-1 pathway on retinal ganglion cells in a mouse model of chronic ocular hypertension
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1094132
Abstract: Purpose In this study, we aimed to investigate whether Programmed cell death 1 ligand 1/programmed cell death 1 ligand 2 (PD-L1/PD-L2) double knockout (dKO) has a protective effect on RGCs in a mouse model of… read more here.
Keywords: model chronic; ocular hypertension; chronic ocular; retinal ganglion ... See more keywords
Elucidation of the Landscape of Alternatively Spliced Genes and Features in the Dorsal Striatum of Aggressive/Aggression-Deprived Mice in the Model of Chronic Social Conflicts
Sign Up to like & getrecommendations! Published in 2023 at "Genes"
DOI: 10.3390/genes14030599
Abstract: Both aggressive and aggression-deprived (AD) individuals represent pathological cases extensively studied in psychiatry and substance abuse disciplines. We employed the animal model of chronic social conflicts curated in our laboratory for over 30 years. In… read more here.
Keywords: model chronic; chronic social; aggressive aggression; aggression deprived ... See more keywords