Repurposing ciclopirox as a pharmacological chaperone in a model of congenital erythropoietic porphyria
Sign Up to like & getrecommendations! Published in 2018 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.aat7467
Abstract: The off-patent marketed antifungal ciclopirox improves symptoms in a mouse model of congenital erythropoietic porphyria. Drug repurposing helps iron out porphyria Porphyria is an inherited incurable disorder resulting from the buildup of heme precursors throughout… read more here.
Keywords: disease; model congenital; congenital erythropoietic; erythropoietic porphyria ... See more keywords
Anxiety and Depression Assessments in a Mouse Model of Congenital Blindness
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2021.807434
Abstract: Previous studies have reported that visual impairment can affect the quality of life leading to mental health disorders. This study aimed to investigate associations between vision impairment, depression and anxiety using a mouse model of… read more here.
Keywords: anxiety; congenital blindness; depression; model congenital ... See more keywords