Effects of cholecalciferol on behavior and production of reactive oxygen species in female mice subjected to corticosterone-induced model of depression
Sign Up to like & getrecommendations! Published in 2019 at "Naunyn-Schmiedeberg's Archives of Pharmacology"
DOI: 10.1007/s00210-019-01714-2
Abstract: Major depressive disorder (or depression) is one of the most frequent psychiatric illnesses in the population, with chronic stress being one of the main etiological factors. Studies have shown that cholecalciferol supplementation can lead to… read more here.
Keywords: depression; production reactive; corticosterone; mice subjected ... See more keywords
Anhedonic-like behavior correlates with IFNγ serum levels in a two-hit model of depression
Sign Up to like & getrecommendations! Published in 2019 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2019.112076
Abstract: Stress is implicated in the etiology of major depressive disorder (MDD) and leads to the activation of proinflammatory pathways, which are recognized to induce depressive symptoms. For instance, depression is commonly observed in patients with… read more here.
Keywords: hit model; model depression; like behavior; serum levels ... See more keywords
Multi-omics Analysis of the Amygdala in a Rat Chronic Unpredictable Mild Stress Model of Depression
Sign Up to like & getrecommendations! Published in 2021 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2021.03.031
Abstract: Major depressive disorder is a serious and complex mental illness, and multiple brain regions are involved in its pathogenesis. There is increasing evidence that the amygdala is involved in depression; however, the underlying molecular mechanisms… read more here.
Keywords: depression; chronic unpredictable; unpredictable mild; model depression ... See more keywords
Evaluation of the effectiveness of chronic antidepressant drug treatments in the hippocampal mitochondria – A proteomic study in an animal model of depression
Sign Up to like & getrecommendations! Published in 2017 at "Progress in Neuro-Psychopharmacology and Biological Psychiatry"
DOI: 10.1016/j.pnpbp.2017.05.014
Abstract: ABSTRACT Several lines of evidence indicate that adverse experience in early life may be a triggering factor for disturbances in the brain mitochondrial proteins and lead to the development of depression in adulthood. On the… read more here.
Keywords: depression; administration; hippocampus; animal model ... See more keywords
Contrasting effects of vortioxetine and paroxetine on pineal gland biochemistry in a tryptophan-depletion model of depression in female rats
Sign Up to like & getrecommendations! Published in 2017 at "Progress in Neuro-Psychopharmacology and Biological Psychiatry"
DOI: 10.1016/j.pnpbp.2017.08.008
Abstract: We studied the effects of the multi-modal antidepressant, vortioxetine and the SSRI, paroxetine on pineal melatonin and monoamine synthesis in a sub-chronic tryptophan (TRP) depletion model of depression based on a low TRP diet. Female… read more here.
Keywords: biochemistry; model depression; pineal; paroxetine pineal ... See more keywords
The asymmetries of the biopsychosocial model of depression in lay discourses - Topic modelling online depression forums
Sign Up to like & getrecommendations! Published in 2021 at "SSM - Population Health"
DOI: 10.1016/j.ssmph.2021.100785
Abstract: Background One of the most comprehensive approaches to depression is the biopsychosocial model. From this wider perspective, social sciences have criticized the reductionist biomedical discourse, which has been dominating expert discourses for a long time.… read more here.
Keywords: depression; biopsychosocial model; model; depression forums ... See more keywords
Escitalopram and NHT normalized stress-induced anhedonia and molecular neuroadaptations in a mouse model of depression
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0188043
Abstract: Anhedonia is defined as a diminished ability to obtain pleasure from otherwise positive stimuli. Anxiety and mood disorders have been previously associated with dysregulation of the reward system, with anhedonia as a core element of… read more here.
Keywords: escitalopram nht; stress induced; stress; model depression ... See more keywords
Paroxetine treatment in an animal model of depression improves sperm quality
Sign Up to like & getrecommendations! Published in 2022 at "PLOS ONE"
DOI: 10.1371/journal.pone.0271217
Abstract: Depression in mammals is known to be associated with poor reproductive capacity. In males, it has been associated with decreased efficiency of spermatogenesis as well as the production of spermatozoa of reduced structural and functional… read more here.
Keywords: paroxetine; depression; animal model; male reproductive ... See more keywords
Hippocampal miR-124 participates in the pathogenesis of depression via regulating the expression of BDNF in a Chronic Social Defeat Stress model of depression.
Sign Up to like & getrecommendations! Published in 2022 at "Current neurovascular research"
DOI: 10.2174/1567202619666220713105306
Abstract: Objective As one of the most prevalent psychiatric disorders, the exact pathogenesis of depression remains elusive. Therefore, there is an urgent need to identify novel antidepressants for effective treatment. MicroRNA-124 (miR-124), the most abundant miRNA… read more here.
Keywords: pathogenesis depression; mir 124; depression; model depression ... See more keywords
Viral metagenomics combined with metabolomics reveals the role of gut viruses in mouse model of depression
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.1046894
Abstract: Depression is a heterogeneous mental disorder that has been linked to disturbances in the gut microbiome. As an essential part of the gut microbiome, gut virome may play critical roles in disease progression and development.… read more here.
Keywords: depression; viral metagenomics; gut virome; model depression ... See more keywords
Cannabidiol Modulates Alterations in PFC microRNAs in a Rat Model of Depression
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24032052
Abstract: Cannabidiol (CBD) is a potential antidepressant agent. We examined the association between the antidepressant effects of CBD and alterations in brain microRNAs in the unpredictable chronic mild stress (UCMS) model for depression. UCMS male rats… read more here.
Keywords: immobility time; 5ht1a receptor; rat model; model ... See more keywords