Ictal vocalizations in the Scn1a+/- mouse model of Dravet syndrome.
Sign Up to like & getrecommendations! Published in 2023 at "Epilepsia open"
DOI: 10.1002/epi4.12715
Abstract: OBJECTIVE Ictal vocalizations have shown diagnostic utility in epilepsy patients. Audio recordings of seizures have also been used for seizure detection. The present study aimed to determine whether generalized tonic-clonic seizures in the Scn1a+/- mouse… read more here.
Keywords: model dravet; seizure; ictal vocalizations; mouse ... See more keywords
Investigating the Therapeutic Mechanism of Cannabidiol in a Human Induced Pluripotent Stem Call (iPSC)-Based Cellular Model of Dravet Syndrome.
Sign Up to like & getrecommendations! Published in 2019 at "Cold Spring Harbor symposia on quantitative biology"
DOI: 10.1101/sqb.2018.83.038174
Abstract: Dravet syndrome is an infantile epileptic encephalopathy primarily caused by loss-of-function variants of the gene SCN1A Standard treatment regimens have very limited efficacy to combat the life-threatening seizures in Dravet syndrome or the behavioral-cognitive comorbidities… read more here.
Keywords: mechanism; model dravet; therapeutic mechanism; cellular model ... See more keywords
Blame it on the Inputs: Overexcited Entorhinal Inputs Drive Dentate Gyrus Hyperexcitability in a Mouse Model of Dravet Syndrome
Sign Up to like & getrecommendations! Published in 2022 at "Epilepsy Currents"
DOI: 10.1177/15357597221112801
Abstract: Corticohippocampal Circuit Dysfunction in a Mouse Model of Dravet Syndrome Mattis J, Somarowthu A, Goff KM, et al. ELife. 2022;11:e69293. doi:10.7554/eLife.69293. Dravet syndrome (DS) is a neurodevelopmental disorder due to pathogenic variants in SCN1A encoding… read more here.
Keywords: model dravet; scn1a mice; pathology; dentate gyrus ... See more keywords