The Role of the Possible Receptors and Intracellular Pathways in Protective Effect of Exogenous Anandamide in Kindling Model of Epilepsy.
Sign Up to like & getrecommendations! Published in 2022 at "Neurochemical research"
DOI: 10.1007/s11064-021-03517-5
Abstract: In this research, the involvement of CB1 and TRPV1 receptors in the possible protective effects of anandamide were investigated in the kindling model of epilepsy. The basolateral amygdala of the rat brain was chosen to… read more here.
Keywords: model epilepsy; group; effect; kindling model ... See more keywords
CRMP2 modulates mossy fiber sprouting in dentate gyrus of pilocarpine induced rat model of epilepsy.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2022.03.071
Abstract: As a hallmark of epilepsy, mossy fiber sprouting was regarded as an ideal mode to study neural rewiring upon injury. The process of mossy fiber sprouting constitutes key steps for neural circuit formation, including axon… read more here.
Keywords: model epilepsy; fiber sprouting; mossy fiber; crmp2 ... See more keywords
Serotonin depletion increases seizure susceptibility and worsens neuropathological outcomes in kainate model of epilepsy
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DOI: 10.1016/j.brainresbull.2017.07.009
Abstract: Serotonin is implicated in the regulation of seizures, but whether or not it can potentiate the effects of epileptogenic factors is not fully established. Using the kainic acid model of epilepsy in rats, we tested… read more here.
Keywords: kainic acid; serotonin; pretreated rats; serotonin depletion ... See more keywords
BAD knockout provides metabolic seizure resistance in a genetic model of epilepsy with sudden unexplained death in epilepsy
Sign Up to like & getrecommendations! Published in 2018 at "Epilepsia"
DOI: 10.1111/epi.13960
Abstract: Metabolic alteration, either through the ketogenic diet (KD) or by genetic alteration of the BAD protein, can produce seizure protection in acute chemoconvulsant models of epilepsy. To assess the seizure‐protective role of knocking out (KO)… read more here.
Keywords: epilepsy; death; model epilepsy; seizure ... See more keywords
Early morphological and functional changes in the GABAergic system of hippocampus in the rat lithium-pilocarpine model of epilepsy
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DOI: 10.1134/s0012496617010045
Abstract: We studied early alterations in the GABAergic system of the rat hippocampus in the lithium–pilocarpine model of epilepsy. Twenty-four hours after the pilocarpine treatment, a decrease in the number of calretinin-positive interneurons was observed in… read more here.
Keywords: gabaergic system; pilocarpine model; lithium pilocarpine; rat ... See more keywords
Effects of dexamethasone on the Li-pilocarpine model of epilepsy: protection against hippocampal inflammation and astrogliosis
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Neuroinflammation"
DOI: 10.1186/s12974-018-1109-5
Abstract: BackgroundTemporal lobe epilepsy (TLE) is the most common form of partial epilepsy and is accompanied, in one third of cases, by resistance to antiepileptic drugs (AED). Most AED target neuronal activity modulated by ionic channels,… read more here.
Keywords: epilepsy; secretion; pilocarpine model; model ... See more keywords
Dogs as a Natural Animal Model of Epilepsy
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DOI: 10.3389/fvets.2022.928009
Abstract: Epilepsy is a common neurological disease in both humans and domestic dogs, making dogs an ideal translational model of epilepsy. In both species, epilepsy is a complex brain disease characterized by an enduring predisposition to… read more here.
Keywords: model epilepsy; epilepsy dogs; epilepsy; medicine ... See more keywords
Silencing of the GluN1-NMDA Glutamate Receptor Subunit by Intranasal siRNA Increases the Latency Time for Seizures in the Pilocarpine Rodent Model of Epilepsy
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DOI: 10.3390/ph15121470
Abstract: Temporal lobe epilepsy (TLE) is the most prevalent and treatment-refractory type of epilepsy. Among the different mechanisms associated with epileptogenesis, overstimulation of glutamatergic neurotransmission has been associated with the onset and progression of seizures in… read more here.
Keywords: model epilepsy; sirna; latency time; subunit ... See more keywords