FMRP(1–297)-tat restores ion channel and synaptic function in a model of Fragile X syndrome
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-16250-4
Abstract: Fragile X Syndrome results from a loss of Fragile X Mental Retardation Protein (FMRP). We now show that FMRP is a member of a Cav3-Kv4 ion channel complex that is known to regulate A-type potassium… read more here.
Keywords: 297 tat; fragile syndrome; ion channel; model fragile ... See more keywords
Impaired perceptual learning in a mouse model of Fragile X syndrome is mediated by parvalbumin neuron dysfunction and is reversible.
Sign Up to like & getrecommendations! Published in 2018 at "Nature neuroscience"
DOI: 10.1038/s41593-018-0231-0
Abstract: To uncover the circuit-level alterations that underlie atypical sensory processing associated with autism, we adopted a symptom-to-circuit approach in the Fmr1-knockout (Fmr1–/–) mouse model of Fragile X syndrome. Using a go/no-go task and in vivo… read more here.
Keywords: mouse model; model fragile; fragile syndrome;
Combined DiI and Antibody Labeling Reveals Complex Dysgenesis of Hippocampal Dendritic Spines in a Mouse Model of Fragile X Syndrome
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10112692
Abstract: Structural, functional, and molecular alterations in excitatory spines are a common hallmark of many neurodevelopmental disorders including intellectual disability and autism. Here, we describe an optimized methodology, based on combined use of DiI and immunofluorescence,… read more here.
Keywords: model fragile; methodology; dysgenesis; mice ... See more keywords