Ursodeoxycholic Acid Binds PERK and Ameliorates Neurite Atrophy in a Cellular Model of GM2 Gangliosidosis
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DOI: 10.3390/ijms24087209
Abstract: The Unfolded protein response (UPR), triggered by stress in the endoplasmic reticulum (ER), is a key driver of neurodegenerative diseases. GM2 gangliosidosis, which includes Tay-Sachs and Sandhoff disease, is caused by an accumulation of GM2,… read more here.
Keywords: gm2 gangliosidosis; cellular model; gangliosidosis; ursodeoxycholic acid ... See more keywords