Tumor suppression effect of targeting periostin with siRNA in a nude mouse model of human laryngeal squamous cell carcinoma
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.22622
Abstract: The incidence of laryngeal carcinoma is increasing, however, the mechanism is not fully understood. We aimed to investigate the efficacy of periostin gene silencing by siRNA on tumor inhibition, in a novel nude mouse model… read more here.
Keywords: nude mouse; laryngeal squamous; carcinoma; human laryngeal ... See more keywords
Empirical model of human blood transverse relaxation at 3 T improves MRI T2 oximetry
Sign Up to like & getrecommendations! Published in 2017 at "Magnetic Resonance in Medicine"
DOI: 10.1002/mrm.26311
Abstract: We sought a human blood T2‐oximetery calibration curve over the wide range of hematocrits commonly found in anemic patients applicable with T2 relaxation under spin tagging (TRUST). read more here.
Keywords: blood transverse; relaxation; empirical model; human blood ... See more keywords
Evolving challenges to model human diseases for translational research
Sign Up to like & getrecommendations! Published in 2020 at "Cell and Tissue Research"
DOI: 10.1007/s00441-019-03134-3
Abstract: Animal models are a significant component of biomedical research and play an important role in translational studies. Traditionally, rodent models have been the mainstay and principal choice of researchers but in recent years, there have… read more here.
Keywords: research; model human; challenges model; evolving challenges ... See more keywords
Bioengineered optogenetic model of human neuromuscular junction.
Sign Up to like & getrecommendations! Published in 2021 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2021.121033
Abstract: Functional human tissues engineered from patient-specific induced pluripotent stem cells (hiPSCs) hold great promise for investigating the progression, mechanisms, and treatment of musculoskeletal diseases in a controlled and systematic manner. For example, bioengineered models of… read more here.
Keywords: optogenetic model; model human; human neuromuscular; bioengineered optogenetic ... See more keywords
Immunohistochemical Validation of Spontaneously Arising Canine Osteosarcoma as a Model for Human Osteosarcoma.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of comparative pathology"
DOI: 10.1016/j.jcpa.2017.07.005
Abstract: Osteosarcoma (OS) originates from bone-forming mesenchymal cells and represents one of the primary bone tumours. It is the most common primary bone tumour in dogs and man. The characterization of an appropriate natural disease animal… read more here.
Keywords: immunohistochemical validation; canine; osteosarcoma; disease ... See more keywords
Parametric exploration of a simple model of human jumping on an oscillating structure
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Sound and Vibration"
DOI: 10.1016/j.jsv.2021.116227
Abstract: Abstract Lightweight and long-span civil structures, such as grandstand tiers, are susceptible to vertical vibrations due to jumping or bobbing of human spectators. After a careful review of experimental evidence, including new data, a simple… read more here.
Keywords: simple model; model human; exploration simple; parametric exploration ... See more keywords
Long-Term Neuroimaging Findings in a Murine Model of Human Extraparenchymal Neurocysticercosis
Sign Up to like & getrecommendations! Published in 2025 at "ACS Infectious Diseases"
DOI: 10.1021/acsinfecdis.5c00431
Abstract: Neurocysticercosis is caused by the establishment of Taenia solium cysticerci in the central nervous system. The extraparenchymal form (ExP-NCC) is the most severe clinical presentation that may remain asymptomatic for years. Current treatment involves cysticidal… read more here.
Keywords: murine model; long term; model human; neurocysticercosis ... See more keywords
A 3D In-vitro model of the human dentine interface shows long-range osteoinduction from the dentine surface
Sign Up to like & getrecommendations! Published in 2024 at "International Journal of Oral Science"
DOI: 10.1038/s41368-024-00298-9
Abstract: Emerging regenerative cell therapies for alveolar bone loss have begun to explore the use of cell laden hydrogels for minimally invasive surgery to treat small and spatially complex maxilla-oral defects. However, the oral cavity presents… read more here.
Keywords: human dentine; vitro model; dentine; dentine interface ... See more keywords
A unified model of human semantic knowledge and its disorders
Sign Up to like & getrecommendations! Published in 2017 at "Nature Human Behaviour"
DOI: 10.1038/s41562-016-0039
Abstract: How is knowledge about the meanings of words and objects represented in the human brain? Current theories embrace two radically different proposals: either distinct cortical systems have evolved to represent different kinds of things, or… read more here.
Keywords: network; unified model; knowledge; human semantic ... See more keywords
In silico model of the human ClC-Kb chloride channel: pore mapping, biostructural pathology and drug screening
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-07794-5
Abstract: The human ClC-Kb channel plays a key role in exporting chloride ions from the cytosol and is known to be involved in Bartter syndrome type 3 when its permeation capacity is decreased. The ClC-Kb channel… read more here.
Keywords: clc; clc channel; pathology; human clc ... See more keywords
A network model for human playfulness during war
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-02634-3
Abstract: This novel study investigates adult playfulness during recent wartime in the Middle East using the OLIW model of playfulness and the concept of fantastic reality ability to utilize imagination in response to stress and trauma.… read more here.
Keywords: war; playfulness; network model; network ... See more keywords