Tumor suppression effect of targeting periostin with siRNA in a nude mouse model of human laryngeal squamous cell carcinoma
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.22622
Abstract: The incidence of laryngeal carcinoma is increasing, however, the mechanism is not fully understood. We aimed to investigate the efficacy of periostin gene silencing by siRNA on tumor inhibition, in a novel nude mouse model… read more here.
Keywords: nude mouse; laryngeal squamous; carcinoma; human laryngeal ... See more keywords
Empirical model of human blood transverse relaxation at 3 T improves MRI T2 oximetry
Sign Up to like & getrecommendations! Published in 2017 at "Magnetic Resonance in Medicine"
DOI: 10.1002/mrm.26311
Abstract: We sought a human blood T2‐oximetery calibration curve over the wide range of hematocrits commonly found in anemic patients applicable with T2 relaxation under spin tagging (TRUST). read more here.
Keywords: blood transverse; relaxation; empirical model; human blood ... See more keywords
Evolving challenges to model human diseases for translational research
Sign Up to like & getrecommendations! Published in 2020 at "Cell and Tissue Research"
DOI: 10.1007/s00441-019-03134-3
Abstract: Animal models are a significant component of biomedical research and play an important role in translational studies. Traditionally, rodent models have been the mainstay and principal choice of researchers but in recent years, there have… read more here.
Keywords: research; model human; challenges model; evolving challenges ... See more keywords
Bioengineered optogenetic model of human neuromuscular junction.
Sign Up to like & getrecommendations! Published in 2021 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2021.121033
Abstract: Functional human tissues engineered from patient-specific induced pluripotent stem cells (hiPSCs) hold great promise for investigating the progression, mechanisms, and treatment of musculoskeletal diseases in a controlled and systematic manner. For example, bioengineered models of… read more here.
Keywords: optogenetic model; model human; human neuromuscular; bioengineered optogenetic ... See more keywords
Immunohistochemical Validation of Spontaneously Arising Canine Osteosarcoma as a Model for Human Osteosarcoma.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of comparative pathology"
DOI: 10.1016/j.jcpa.2017.07.005
Abstract: Osteosarcoma (OS) originates from bone-forming mesenchymal cells and represents one of the primary bone tumours. It is the most common primary bone tumour in dogs and man. The characterization of an appropriate natural disease animal… read more here.
Keywords: immunohistochemical validation; canine; osteosarcoma; disease ... See more keywords
Parametric exploration of a simple model of human jumping on an oscillating structure
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Sound and Vibration"
DOI: 10.1016/j.jsv.2021.116227
Abstract: Abstract Lightweight and long-span civil structures, such as grandstand tiers, are susceptible to vertical vibrations due to jumping or bobbing of human spectators. After a careful review of experimental evidence, including new data, a simple… read more here.
Keywords: simple model; model human; exploration simple; parametric exploration ... See more keywords
A unified model of human semantic knowledge and its disorders
Sign Up to like & getrecommendations! Published in 2017 at "Nature Human Behaviour"
DOI: 10.1038/s41562-016-0039
Abstract: How is knowledge about the meanings of words and objects represented in the human brain? Current theories embrace two radically different proposals: either distinct cortical systems have evolved to represent different kinds of things, or… read more here.
Keywords: network; unified model; knowledge; human semantic ... See more keywords
In silico model of the human ClC-Kb chloride channel: pore mapping, biostructural pathology and drug screening
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-07794-5
Abstract: The human ClC-Kb channel plays a key role in exporting chloride ions from the cytosol and is known to be involved in Bartter syndrome type 3 when its permeation capacity is decreased. The ClC-Kb channel… read more here.
Keywords: clc; clc channel; pathology; human clc ... See more keywords
Global vs local control of cardiac alternans in a 1D numerical model of human ventricular tissue.
Sign Up to like & getrecommendations! Published in 2020 at "Chaos"
DOI: 10.1063/5.0005432
Abstract: Cardiac alternans is a proarrhythmic state in which the action potential duration (APD) of cardiac myocytes alternate between long and short values and often occurs under conditions of rapid pacing of cardiac tissue. In the… read more here.
Keywords: constant pacing; tissue; model human; cardiac alternans ... See more keywords
A vascularized model of the human liver mimics regenerative responses
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2115867119
Abstract: Significance Liver disease causes ∼2 million annual deaths, yet medical treatments and transplantable organs are both lacking. The liver can regenerate when mature hepatocytes divide, and while this process is well studied in rodents, parallel… read more here.
Keywords: liver; model human; human liver; vascularized model ... See more keywords
Hindsight Experience Replay Improves Reinforcement Learning for Control of a MIMO Musculoskeletal Model of the Human Arm
Sign Up to like & getrecommendations! Published in 2021 at "IEEE Transactions on Neural Systems and Rehabilitation Engineering"
DOI: 10.1109/tnsre.2021.3081056
Abstract: High-level spinal cord injuries often result in paralysis of all four limbs, leading to decreased patient independence and quality of life. Coordinated functional electrical stimulation (FES) of paralyzed muscles can be used to restore some… read more here.
Keywords: musculoskeletal model; experience replay; reinforcement learning; hindsight experience ... See more keywords