Pyroptotic cell death in the R6/2 mouse model of Huntington's disease: new insight on the inflammasome.
Sign Up to like & getrecommendations! Published in 2020 at "Cell death discovery"
DOI: 10.1038/s41420-020-00293-z
Abstract: Mechanisms of tissue damage in Huntington's disease involve excitotoxicity, mitochondrial damage, and neuroinflammation, including microglia activation. In the present study, we investigate the role of pyroptosis process in the striatal neurons of the R6/2 mouse… read more here.
Keywords: model huntington; huntington disease; huntington; cell death ... See more keywords
A pig model of Huntington’s disease
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DOI: 10.1038/s41591-018-0119-2
Abstract: Knock-in of the huntingtin gene in pigs recreates key features of Huntington’s disease. Huntington’s disease is a severe neurodegenerative monogenetic disease that results in age-dependent selective neuronal loss in affected individuals—a feature that cannot be… read more here.
Keywords: model huntington; huntington disease; pig model; disease ... See more keywords
Circadian and ultradian rhythms in normal mice and in a mouse model of Huntington’s disease
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DOI: 10.1080/07420528.2021.2014516
Abstract: ABSTRACT Circadian rhythms in core body temperature (CBT) have been widely studied, but fewer studies have explored higher-frequency (ultradian) rhythms in detail. We analyzed CBT recordings from young and middle-aged wild-type mice as well as… read more here.
Keywords: huntington disease; ultradian rhythms; model huntington; rhythms ... See more keywords
Structural and functional features of medium spiny neurons in the BACHDΔN17 mouse model of Huntington’s Disease
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DOI: 10.1371/journal.pone.0234394
Abstract: In the BACHD mouse model of Huntington’s disease (HD), deletion of the N17 domain of the Huntingtin gene (BACHDΔN17, Q97) has been reported to lead to nuclear accumulation of mHTT and exacerbation of motor deficits,… read more here.
Keywords: model huntington; bachd n17; q97; mouse model ... See more keywords