An adenine model of inborn metabolism errors alters TDP-43 aggregation and reduces its toxicity in yeast revealing insights into protein misfolding diseases
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DOI: 10.15698/mic2025.05.850
Abstract: Abstract TDP-43 is linked to human diseases such as amyotrophic lateral sclerosis (ALS) and frontotemporal degeneration (FTD). Expression of TDP-43 in yeast is known to be toxic, cause cells to elongate, form liquid-like aggregates, and… read more here.
Keywords: protein misfolding; misfolding diseases; model inborn; toxicity ... See more keywords