Development of a model of ischemic heart disease using cardiomyocytes differentiated from human induced pluripotent stem cells.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.09.119
Abstract: Ischemic heart disease remains the largest cause of death worldwide. Accordingly, many researchers have sought curative options, often using laboratory animal models such as rodents. However, the physiology of the human heart differs significantly from… read more here.
Keywords: heart disease; heart; model ischemic; ischemic heart ... See more keywords
An endovascular model of ischemic myopathy from peripheral arterial disease: From the Southern Association for Vascular Surgery
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Vascular Surgery"
DOI: 10.1016/j.jvs.2016.07.127
Abstract: Objective: Peripheral arterial disease (PAD) is a significant age‐related medical condition with limited pharmacologic options. Severe PAD, termed critical limb ischemia, can lead to amputation. Skeletal muscle is the end organ most affected by PAD,… read more here.
Keywords: model ischemic; model; pad; ischemic myopathy ... See more keywords
Neuroprotective effect of hypoxic preconditioning and neuronal activation in a in vitro human model of the ischemic penumbra
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DOI: 10.1088/1741-2552/abe68a
Abstract: Objective. In ischemic stroke, treatments to protect neurons from irreversible damage are urgently needed. Studies in animal models have shown that neuroprotective treatments targeting neuronal silencing improve brain recovery, but in clinical trials none of… read more here.
Keywords: ischemic penumbra; hypoxic preconditioning; model ischemic; human neuronal ... See more keywords
t-PA Suppresses the Immune Response and Aggravates Neurological Deficit in a Murine Model of Ischemic Stroke
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2019.00591
Abstract: Introduction: Acute ischemic stroke (AIS) is a potent trigger of immunosuppression, resulting in increased infection risk. While thrombolytic therapy with tissue-type plasminogen activator (t-PA) is still the only pharmacological treatment for AIS, plasmin, the effector… read more here.
Keywords: ischemic stroke; model ischemic; treatment; immune response ... See more keywords
Re-Evaluating the Relevance of the Oxygen–Glucose Deprivation Model in Ischemic Stroke: The Example of Cdk Inhibition
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24087009
Abstract: Previous research has shown that cyclin-dependent kinases (Cdks) that play physiological roles in cell cycle regulation become activated in post-mitotic neurons after ischemic stroke, resulting in apoptotic neuronal death. In this article, we report our… read more here.
Keywords: glucose deprivation; model ischemic; oxygen glucose; model ... See more keywords