Early-age Ndufs4 knockout mice are an inappropriate animal model of Leigh syndrome
Sign Up to like & getrecommendations! Published in 2019 at "Radiological Physics and Technology"
DOI: 10.1007/s12194-019-00511-z
Abstract: Letter to the Editor With interest, we read the article by Saito et al. about a study applying chemical exchange saturation transfer (CEST) and magnetic resonance spectroscopy (MRS) using 7T magnetic resonance imaging (MRI) in… read more here.
Keywords: leigh syndrome; model leigh; lactate; mrs ... See more keywords
Mitochondrial Proteome of Affected Glutamatergic Neurons in a Mouse Model of Leigh Syndrome
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2020.00660
Abstract: Defects in mitochondrial function lead to severe neuromuscular orphan pathologies known as mitochondrial disease. Among them, Leigh Syndrome is the most common pediatric presentation, characterized by symmetrical brain lesions, hypotonia, motor and respiratory deficits, and… read more here.
Keywords: leigh syndrome; model leigh; neurons mouse; model ... See more keywords