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   Articles with "model sepsis" as a keyword



CSN6 aggravates inflammation and Myocardial injury in macrophage of sepsis model by MIF

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recommendations! Published in 2025 at "Scientific Reports"

DOI: 10.1038/s41598-025-07339-1

Abstract: Sepsis, one of the leading causes of death in critically ill patients, is characterized by multiple organ dysfunction due to a dysregulated immune response to infection. Caregivers closely monitor patients’ organ function indicators in the… read more here.

Keywords: model sepsis; mif; csn6; vitro model ... See more keywords

Modulation of microglial phenotypes improves sepsis-induced hippocampus- dependent cognitive impairments and decreases brain inflammation in an animal model of sepsis.

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recommendations! Published in 2020 at "Clinical science"

DOI: 10.1042/cs20191322

Abstract: BACKGROUND In order to modulate microglial phenotypes in vivo, M1 microglia were depleted by administration of gadolinium chloride and the expression of M2 microglia was induced by IL-4 administration in an animal model of sepsis… read more here.

Keywords: model sepsis; sepsis induced; sepsis; microglial phenotypes ... See more keywords

RNF20 deletion causes inflammation in model of sepsis through the NLRP3 Activation.

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recommendations! Published in 2023 at "Immunopharmacology and immunotoxicology"

DOI: 10.1080/08923973.2023.2170241

Abstract: Sepsis is an extremely complex, threatening and difficult-to-treat disease, which can occur at any age and under any underlying disease. RNF20 regulate NF-kappaB (NF-κB) signaling pathway and the transcription of inflammatory factors of target genes.… read more here.

Keywords: sepsis; rnf20; model sepsis; inflammation reactions ... See more keywords
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Induction of the NEK family of kinases in the lungs of mice subjected to cecal ligation and puncture model of sepsis.

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recommendations! Published in 2021 at "Tissue barriers"

DOI: 10.1080/21688370.2021.1929787

Abstract: Endothelial barrier dysfunction (EBD) is the hallmark of Acute Respiratory Distress Syndrome (ARDS), a potentially lethal respiratory disorder associated with the COVID-19 - related deaths. Herein, we employed a cecal ligation and puncture (CLP) murine… read more here.

Keywords: sepsis; cecal ligation; ligation puncture; model sepsis ... See more keywords

S100A12 as a key biomarker in a neutrophil-associated gene prediction model for sepsis diagnosis

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recommendations! Published in 2025 at "Medicine"

DOI: 10.1097/md.0000000000046140

Abstract: Sepsis is a life-threatening organ dysfunction syndrome caused by a dysregulated host response to infection. As a leading cause of mortality in intensive care units patients, it still lacks sensitive biomarkers. Therefore, this study aimed… read more here.

Keywords: model sepsis; key biomarker; neutrophil associated; model ... See more keywords

Assessing the effects of fluids and antibiotics in an acute murine model of sepsis: study protocol for the National Preclinical Sepsis Platform-01 (NPSP-01) Study

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recommendations! Published in 2025 at "F1000Research"

DOI: 10.12688/f1000research.163800.1

Abstract: Background Sepsis remains a leading cause of mortality in critical care. Despite extensive preclinical research on sepsis pathophysiology, the development of effective therapies has been largely unsuccessful. Key obstacles include limited construct validity of animal… read more here.

Keywords: model sepsis; sepsis; research; study ... See more keywords

Renal protective effects of zingerone in a mouse model of sepsis

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recommendations! Published in 2019 at "BMB Reports"

DOI: 10.5483/bmbrep.2019.52.4.175

Abstract: Zingerone (ZGR), a phenolic alkanone isolated from ginger, has been reported to possess pharmacological activities such as anti-inflammatory and anti-apoptotic effects. This study was initiated to determine whether ZGR could modulate renal functional damage in… read more here.

Keywords: model sepsis; sepsis; zingerone; mouse model ... See more keywords

4-Octyl itaconate regulates immune balance by activating Nrf2 and negatively regulating PD-L1 in a mouse model of sepsis

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recommendations! Published in 2022 at "International Journal of Biological Sciences"

DOI: 10.7150/ijbs.74456

Abstract: Introduction: Sepsis is a major global health challenge with high mortality rates and no effective treatment. Recent studies have suggested that sepsis may be associated with immune system dysfunction. Itaconate may exert anti-inflammatory effects via… read more here.

Keywords: sepsis; mouse model; anti inflammatory; activating nrf2 ... See more keywords