NAD-biosynthetic enzyme NMNAT1 reduces early behavioral impairment in the htau mouse model of tauopathy
Sign Up to like & getrecommendations! Published in 2018 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2017.11.030
Abstract: HIGHLIGHTSFirst investigation of the role of NMNAT1 in the early stage of tauopathies in mice.htau mice display a robust deficit in food burrowing prior to onset of cognitive symptoms.NMNAT1 overexpression rescues this behavioral abnormality. ABSTRACT… read more here.
Keywords: nad biosynthetic; htau mice; model tauopathy; nmnat1 ... See more keywords
SMaRT modulation of tau isoforms rescues cognitive and motor impairments in a preclinical model of tauopathy
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Bioengineering and Biotechnology"
DOI: 10.3389/fbioe.2022.951384
Abstract: Tau is a microtubule-associated protein predominantly expressed in neurons, which participates in microtubule polymerization and axonal transport. Abnormal tau metabolism leads to neurodegenerative diseases named tauopathies, such as Alzheimer’s disease and frontotemporal dementia. The alternative… read more here.
Keywords: tau; modulation; htau mice; motor ... See more keywords
Altered Brain Metabolome Is Associated with Memory Impairment in the rTg4510 Mouse Model of Tauopathy
Sign Up to like & getrecommendations! Published in 2020 at "Metabolites"
DOI: 10.3390/metabo10020069
Abstract: Alzheimer’s disease (AD) is characterized, amongst other features, by the pathologic accumulation of abnormally phosphorylated tau filaments in neurons that lead to neurofibrillary tangles. However, the molecular mechanisms by which the abnormal processing of tau… read more here.
Keywords: memory impairment; rtg4510; impairment; altered brain ... See more keywords