A spatial-temporal model for zonal hepatotoxicity of acetaminophen.
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DOI: 10.1016/j.dmpk.2018.09.266
Abstract: The metabolism zonation in liver lobules is well known yet its incorporation into the mathematical models of acetaminophen (APAP) metabolism is still primitive - only the oxidation pathway via reaction with the cytochrome P450 (CYP450)… read more here.
Keywords: metabolism; spatial temporal; model; hepatotoxicity ... See more keywords