Bottom–up modeling of chromatin segregation due to epigenetic modifications
Sign Up to like & getrecommendations! Published in 2018 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1812268115
Abstract: Significance Predicting how epigenetic marks control the 3D organization of the genome is key to understanding how these marks regulate gene expression. We show that a physical model of a chromosome with experimentally measured local… read more here.
Keywords: segregation due; heterochromatin; chromatin segregation; modeling chromatin ... See more keywords
Physical constraints in polymer modeling of chromatin associations with the nuclear periphery at kilobase scale
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DOI: 10.1080/19491034.2020.1868105
Abstract: ABSTRACT Interactions of chromatin with the nuclear lamina imposes a radial genome distribution important for nuclear functions. How physical properties of chromatin affect these interactions is unclear. We used polymer simulations to model how physical… read more here.
Keywords: physical constraints; polymer modeling; associations nuclear; chromatin associations ... See more keywords