Molecular modeling and docking of recombinant HAP-phytase of a thermophilic mould Sporotrichum thermophile reveals insights into molecular catalysis and biochemical properties.
Sign Up to like & getrecommendations! Published in 2018 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2018.04.086
Abstract: A thermostable and protease-resistant HAP-phytase of Sporotrichum thermophile was over-expressed in Pichia pastoris X-33. Purified recombinant phytase displayed all its biochemical properties similar to wild type. Molecular modeling and docking of phytase with various substrates… read more here.
Keywords: hap phytase; molecular modeling; phytase; modeling docking ... See more keywords
In Silico Modeling and Docking Analysis of CTX-M-5, Cefotaxime-Hydrolyzing β-Lactamase from Human-Associated Salmonella Typhimurium
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Pharmacology and Pharmacotherapeutics"
DOI: 10.1177/0976500x221109721
Abstract: Objective: To computationally model the CTX-M-5 β-lactamase and establish its structure, which is exclusively present in human-associated Salmonella. Methods: The CTX-M-5 aminoacid sequence (Uniprot ID:O65975) of Salmonella enterica subsp. enterica serovar typhimurium was retrieved from… read more here.
Keywords: salmonella; associated salmonella; silico modeling; typhimurium ... See more keywords
Molecular Modeling and Docking of Aquaporin Inhibitors to Reveal New Insights Into Schistosomiasis Treatment.
Sign Up to like & getrecommendations! Published in 2019 at "Current computer-aided drug design"
DOI: 10.2174/1573409915666191003124947
Abstract: Schistosomiasis (snail fever/bilharzia), a disease caused by parasitic flatworms (schistosomes), infects millions of people worldwide. Aquaporins from these organisms were found to be a potent drug target. We investigate the possible mechanism of inhibition of… read more here.
Keywords: schistosomiasis; molecular modeling; docking aquaporin; modeling docking ... See more keywords
Homology Modeling and Docking Studies to Identify the Targets in Pancreatic Cancer
Sign Up to like & getrecommendations! Published in 2017 at "Research Journal of Pharmacy and Technology"
DOI: 10.5958/0974-360x.2017.00355.9
Abstract: Pancreatic cancer is the leading cause of cancer related deaths. Metastasis and drug resistance are the major causes of mortality in patients with pancreatic cancer. There are several genes which are responsible for causing pancreatic… read more here.
Keywords: modeling docking; docking studies; pancreatic cancer; homology modeling ... See more keywords