Multi-scale modeling of drug binding kinetics to predict drug efficacy
Sign Up to like & getrecommendations! Published in 2019 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-019-03376-y
Abstract: Optimizing drug therapies for any disease requires a solid understanding of pharmacokinetics (the drug concentration at a given time point in different body compartments) and pharmacodynamics (the effect a drug has at a given concentration).… read more here.
Keywords: drug binding; drug; binding kinetics; drug efficacy ... See more keywords
Modeling drug addiction in females: how internal state and environmental context facilitate vulnerability
Sign Up to like & getrecommendations! Published in 2018 at "Current Opinion in Behavioral Sciences"
DOI: 10.1016/j.cobeha.2018.02.003
Abstract: A fundamental aspect of survival is the ability to refine behaviors based on internal and external contexts. Interpretation of rewarding stimuli is driven by integration of a diverse number of inputs including contextual cues, hormone… read more here.
Keywords: addiction; context; addiction females; vulnerability ... See more keywords
Modeling drug combination effects via latent tensor reconstruction
Sign Up to like & getrecommendations! Published in 2021 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btab308
Abstract: Abstract Motivation Combination therapies have emerged as a powerful treatment modality to overcome drug resistance and improve treatment efficacy. However, the number of possible drug combinations increases very rapidly with the number of individual drugs… read more here.
Keywords: combination; tensor; drug; drug combination ... See more keywords